IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v458y2009i7238d10.1038_nature07746.html
   My bibliography  Save this article

Adaptation of HIV-1 to human leukocyte antigen class I

Author

Listed:
  • Yuka Kawashima

    (Divisions of Viral Immunology and,)

  • Katja Pfafferott

    (Department of Paediatrics,
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University)

  • John Frater

    (Nuffield Department of Clinical Medicine and,
    The James Martin 21st Century School, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK)

  • Philippa Matthews

    (Department of Paediatrics,)

  • Rebecca Payne

    (Department of Paediatrics,)

  • Marylyn Addo

    (Partners AIDS Research Center, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Boston, Massachusetts 02129, USA)

  • Hiroyuki Gatanaga

    (Infectious Disease, Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan
    AIDS Clinical Center, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan)

  • Mamoru Fujiwara

    (Divisions of Viral Immunology and,)

  • Atsuko Hachiya

    (Divisions of Viral Immunology and,
    AIDS Clinical Center, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan)

  • Hirokazu Koizumi

    (Divisions of Viral Immunology and,)

  • Nozomi Kuse

    (Divisions of Viral Immunology and,)

  • Shinichi Oka

    (Infectious Disease, Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Kumamoto 860-0811, Japan
    AIDS Clinical Center, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan)

  • Anna Duda

    (Nuffield Department of Clinical Medicine and,
    The James Martin 21st Century School, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK)

  • Andrew Prendergast

    (Department of Paediatrics,)

  • Hayley Crawford

    (Department of Paediatrics,)

  • Alasdair Leslie

    (Department of Paediatrics,)

  • Zabrina Brumme

    (Partners AIDS Research Center, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Boston, Massachusetts 02129, USA)

  • Chanson Brumme

    (Partners AIDS Research Center, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Boston, Massachusetts 02129, USA)

  • Todd Allen

    (Partners AIDS Research Center, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Boston, Massachusetts 02129, USA)

  • Christian Brander

    (Partners AIDS Research Center, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Boston, Massachusetts 02129, USA
    Fundació IrsiCaixa-HIVACAT, Hospital Germans Trias i Pujol, Badalona and Institucio Catalana de Recerca i Estudis Avancats (ICREA))

  • Richard Kaslow

    (University of Alabama at Birmingham, Birmingham, Alabama 35294, USA)

  • James Tang

    (University of Alabama at Birmingham, Birmingham, Alabama 35294, USA)

  • Eric Hunter

    (Emory University Vaccine Center and Yerkes National Primate Research Center, Atlanta, Georgia 30329, USA)

  • Susan Allen

    (Zambia Emory HIV Research Project, and the Zambia Blood Transfusion Service)

  • Joseph Mulenga

    (Zambia Emory HIV Research Project, and the Zambia Blood Transfusion Service)

  • Songee Branch

    (Ladymeade Reference Unit, University of West Indies)

  • Tim Roach

    (Ladymeade Reference Unit, University of West Indies)

  • Mina John

    (Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University)

  • Simon Mallal

    (Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University)

  • Anthony Ogwu

    (Botswana-Harvard School of Public Health AIDS Initiative Partnership)

  • Roger Shapiro

    (Botswana-Harvard School of Public Health AIDS Initiative Partnership)

  • Julia G. Prado

    (Department of Paediatrics,)

  • Sarah Fidler

    (Wright Fleming Institute, Imperial College, St Mary’s Hospital, Norfolk Place, Paddington, London W2 1PG, UK)

  • Jonathan Weber

    (Wright Fleming Institute, Imperial College, St Mary’s Hospital, Norfolk Place, Paddington, London W2 1PG, UK)

  • Oliver G. Pybus

    (University of Oxford, South Parks Road, Oxford OX1 3SY, UK)

  • Paul Klenerman

    (Nuffield Department of Clinical Medicine and,
    The James Martin 21st Century School, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK)

  • Thumbi Ndung’u

    (HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal)

  • Rodney Phillips

    (Nuffield Department of Clinical Medicine and,
    The James Martin 21st Century School, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, UK)

  • David Heckerman

    (BC Centre for Excellence in HIV/AIDS, Vancouver, British Columbia V6Z 1Y6, Canada)

  • P. Richard Harrigan

    (Miscrosoft Research, One Microsoft Way, Redmond, Washington 9805, USA)

  • Bruce D. Walker

    (Partners AIDS Research Center, Massachusetts General Hospital, 13th Street, Building 149, Charlestown, Boston, Massachusetts 02129, USA
    HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20185, USA)

  • Masafumi Takiguchi

    (Divisions of Viral Immunology and,)

  • Philip Goulder

    (Department of Paediatrics,
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University
    HIV Pathogenesis Programme, The Doris Duke Medical Research Institute, University of KwaZulu-Natal)

Abstract

HIV a moving target In order to determine whether HIV is adapting to the human leukocyte antigen (HLA) alleles, such as HLA-B*57, B*57 and B*51, that mediate successful control of the virus, viral sequences and HLA types were analysed in more than 500 HIV-infected subjects drawn from North America, the Caribbean, Europe, Africa, Australasia and Asia. The results reveal that HIV is evolving at the population level in response to immune selection pressure. Whilst this does not indicate that HIV is necessarily 'winning' the evolutionary struggle against humans, it does suggest that successful HIV vaccines — like those against influenza — will need to keep pace with a changing immunological landscape.

Suggested Citation

  • Yuka Kawashima & Katja Pfafferott & John Frater & Philippa Matthews & Rebecca Payne & Marylyn Addo & Hiroyuki Gatanaga & Mamoru Fujiwara & Atsuko Hachiya & Hirokazu Koizumi & Nozomi Kuse & Shinichi Ok, 2009. "Adaptation of HIV-1 to human leukocyte antigen class I," Nature, Nature, vol. 458(7238), pages 641-645, April.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7238:d:10.1038_nature07746
    DOI: 10.1038/nature07746
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07746
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07746?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Elham Khatamzas & Markus H. Antwerpen & Alexandra Rehn & Alexander Graf & Johannes Christian Hellmuth & Alexandra Hollaus & Anne-Wiebe Mohr & Erik Gaitzsch & Tobias Weiglein & Enrico Georgi & Clemens , 2022. "Accumulation of mutations in antibody and CD8 T cell epitopes in a B cell depleted lymphoma patient with chronic SARS-CoV-2 infection," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:458:y:2009:i:7238:d:10.1038_nature07746. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.