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Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells

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  • Daniel A. Lim

    (Department of Neurological Surgery,
    Institute for Regeneration Medicine, and,
    Veteran’s Affairs Medical Center, University of California, San Francisco, 505 Parnassus Street M779, San Francisco, California 94143, USA)

  • Yin-Cheng Huang

    (Department of Neurological Surgery,
    Institute for Regeneration Medicine, and,
    Present address: Department of Neurosurgery, Graduate Institute of Clinical Medical Science, ChangGung Univerisity, Kwei-Shan, Tao-yuan, Taiwan.)

  • Tomek Swigut

    (Stanford, California 94305, USA)

  • Anika L. Mirick

    (Dartmouth Medical School, Hanover, New Hampshire 03755, USA)

  • Jose Manuel Garcia-Verdugo

    (Laboratorio de Neurobiologia Comparada, Instituto Cavanilles, Universidad de Valencia
    Laboratorio de Morfologia Celular, Centro de Investigación Príncipe Felipe, CIBERNED, Valencia 46012, Spain)

  • Joanna Wysocka

    (Stanford, California 94305, USA)

  • Patricia Ernst

    (Dartmouth Medical School, Hanover, New Hampshire 03755, USA)

  • Arturo Alvarez-Buylla

    (Department of Neurological Surgery,
    Institute for Regeneration Medicine, and,)

Abstract

New neurons It is now accepted that the adult brain has the plasticity to grow new cells, but the molecular mechanisms that maintain neurogenesis throughout life in certain brain regions are not known. One major influence on gene expression the structure of chromatin — the complex of nucleotides and protein that make up chromosomes. Lim et al. now show that in the postnatal mouse brain, the chromatin remodelling factor gene Mll1 (mixed lineage leukaemia 1) prompts neural stem cells to form neurons, whereas in the absence of Mll1 the same stem cells produce glial cells, the non-neuronal cells that play a primarily supportive role the nervous system. Mll1 operates in part by activating the downstream gene Dlx2, a key regulator of neurogenesis in the subventricular zone of the brain.

Suggested Citation

  • Daniel A. Lim & Yin-Cheng Huang & Tomek Swigut & Anika L. Mirick & Jose Manuel Garcia-Verdugo & Joanna Wysocka & Patricia Ernst & Arturo Alvarez-Buylla, 2009. "Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells," Nature, Nature, vol. 458(7237), pages 529-533, March.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7237:d:10.1038_nature07726
    DOI: 10.1038/nature07726
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    Cited by:

    1. Ting Zhao & Yan Hong & Bowen Yan & Suming Huang & Guo-li Ming & Hongjun Song, 2024. "Epigenetic maintenance of adult neural stem cell quiescence in the mouse hippocampus via Setd1a," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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