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Specific synapses develop preferentially among sister excitatory neurons in the neocortex

Author

Listed:
  • Yong-Chun Yu

    (Developmental Biology Program, Memorial Sloan Kettering Cancer Centre, 1275 York Avenue)

  • Ronald S. Bultje

    (Developmental Biology Program, Memorial Sloan Kettering Cancer Centre, 1275 York Avenue
    Weill Medical College of Cornell University, 445 East 69th Street, New York, New York 10065, USA)

  • Xiaoqun Wang

    (Developmental Biology Program, Memorial Sloan Kettering Cancer Centre, 1275 York Avenue)

  • Song-Hai Shi

    (Developmental Biology Program, Memorial Sloan Kettering Cancer Centre, 1275 York Avenue)

Abstract

Neocortical organization: built with columns The neocortex functions as the executive control centre of the brain in mammals, contributing critically to perception and behaviour. Its structure is complex yet highly organized, though the factors regulating cortical microcircuitry wiring relationships remain poorly understood. A new study in mouse embryos reveals that neurons originating from the same progenitor cell (ontogenetic radial clones) within the developing neocortex are more likely to be synaptically connected to each other than to non-sibling neurons, resulting in the formation of functional columnar microstructures with single-cell resolution.

Suggested Citation

  • Yong-Chun Yu & Ronald S. Bultje & Xiaoqun Wang & Song-Hai Shi, 2009. "Specific synapses develop preferentially among sister excitatory neurons in the neocortex," Nature, Nature, vol. 458(7237), pages 501-504, March.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7237:d:10.1038_nature07722
    DOI: 10.1038/nature07722
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    Cited by:

    1. Yoav Printz & Pritish Patil & Mathias Mahn & Asaf Benjamin & Anna Litvin & Rivka Levy & Max Bringmann & Ofer Yizhar, 2023. "Determinants of functional synaptic connectivity among amygdala-projecting prefrontal cortical neurons in male mice," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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