Author
Listed:
- Maria-Carla Saleh
(University of California, San Francisco 94122-2280, USA
Present addresses: Institut Pasteur, Viruses and RNA interference, F-75015 Paris, France (M.-C.S.); Department of Medical Microbiology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands (R.P.v.R.).)
- Michel Tassetto
(University of California, San Francisco 94122-2280, USA)
- Ronald P. van Rij
(University of California, San Francisco 94122-2280, USA
Present addresses: Institut Pasteur, Viruses and RNA interference, F-75015 Paris, France (M.-C.S.); Department of Medical Microbiology, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands (R.P.v.R.).)
- Bertsy Goic
(Institut Pasteur, Viruses and RNA interference, F-75015 Paris, France)
- Valérie Gausson
(Institut Pasteur, Viruses and RNA interference, F-75015 Paris, France)
- Bassam Berry
(Institut Pasteur, Drosophila Genetics and Epigenetics; CNRS, URA 2578, F-75015 Paris, France
CNRS, URA 2578, F-75015 Paris, France)
- Caroline Jacquier
(Institut Pasteur, Drosophila Genetics and Epigenetics; CNRS, URA 2578, F-75015 Paris, France
CNRS, URA 2578, F-75015 Paris, France)
- Christophe Antoniewski
(Institut Pasteur, Drosophila Genetics and Epigenetics; CNRS, URA 2578, F-75015 Paris, France
CNRS, URA 2578, F-75015 Paris, France)
- Raul Andino
(University of California, San Francisco 94122-2280, USA)
Abstract
Antiviral RNAi in insects Drosophila and other insects are known to be able to mount a local antiviral defence involving RNA interference (RNAi). It was previously thought that Drosophila is unable to systemically spread an RNAi response, based on observations that endogenously expressed RNA hairpins did not spread from cell to cell. But experiments involving challenge with Sindbis and Drosophila C viruses now show that D. melanogaster can also generate a systemic RNAi response. This suggests that the RNA silencing component of immunity in vertebrates and invertebrates may be more highly conserved than was thought.
Suggested Citation
Maria-Carla Saleh & Michel Tassetto & Ronald P. van Rij & Bertsy Goic & Valérie Gausson & Bassam Berry & Caroline Jacquier & Christophe Antoniewski & Raul Andino, 2009.
"Antiviral immunity in Drosophila requires systemic RNA interference spread,"
Nature, Nature, vol. 458(7236), pages 346-350, March.
Handle:
RePEc:nat:nature:v:458:y:2009:i:7236:d:10.1038_nature07712
DOI: 10.1038/nature07712
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Cited by:
- Tsubasa Tanaka & Tamaki Yano & Shingo Usuki & Yoko Seo & Kento Mizuta & Maho Okaguchi & Maki Yamaguchi & Kazuko Hanyu-Nakamura & Noriko Toyama-Sorimachi & Katja Brückner & Akira Nakamura, 2024.
"Endocytosed dsRNAs induce lysosomal membrane permeabilization that allows cytosolic dsRNA translocation for Drosophila RNAi responses,"
Nature Communications, Nature, vol. 15(1), pages 1-14, December.
- Shengzhang Dong & George Dimopoulos, 2023.
"Aedes aegypti Argonaute 2 controls arbovirus infection and host mortality,"
Nature Communications, Nature, vol. 14(1), pages 1-16, December.
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