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Enhancing SIV-specific immunity in vivo by PD-1 blockade

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Listed:
  • Vijayakumar Velu

    (Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA)

  • Kehmia Titanji

    (Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA)

  • Baogong Zhu

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Sajid Husain

    (Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA)

  • Annette Pladevega

    (Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA)

  • Lilin Lai

    (Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA)

  • Thomas H. Vanderford

    (University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA)

  • Lakshmi Chennareddi

    (Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA)

  • Guido Silvestri

    (University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA)

  • Gordon J. Freeman

    (Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Rafi Ahmed

    (Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA)

  • Rama Rao Amara

    (Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA)

Abstract

Immunity boost in HIV/AIDS Blockade of PD-1 (programmed death-1), a B7/CD28 family immune-receptor molecule that inhibits the immune response to chronic viral infections, is shown to improve anti-viral immune responses in SIV-infected macaques without adverse side effects. The treatment, which used an antibody specific to human PD-1, also prolonged survival. PD-1 blockade was effective without antiretroviral drugs, suggesting that a similar approach might also be effective in HIV/AIDS patients, combined perhaps with drugs or therapeutic vaccination.

Suggested Citation

  • Vijayakumar Velu & Kehmia Titanji & Baogong Zhu & Sajid Husain & Annette Pladevega & Lilin Lai & Thomas H. Vanderford & Lakshmi Chennareddi & Guido Silvestri & Gordon J. Freeman & Rafi Ahmed & Rama Ra, 2009. "Enhancing SIV-specific immunity in vivo by PD-1 blockade," Nature, Nature, vol. 458(7235), pages 206-210, March.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7235:d:10.1038_nature07662
    DOI: 10.1038/nature07662
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    Cited by:

    1. David Gardiner & Jay Lalezari & Eric Lawitz & Michael DiMicco & Rheem Ghalib & K Rajender Reddy & Kyong-Mi Chang & Mark Sulkowski & Steven O’ Marro & Jeffrey Anderson & Bing He & Vikram Kansra & Fiona, 2013. "A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus Infection," PLOS ONE, Public Library of Science, vol. 8(5), pages 1-11, May.

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