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Complete but curtailed T-cell response to very low-affinity antigen

Author

Listed:
  • Dietmar Zehn

    (Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, Washington 98195, USA)

  • Sarah Y. Lee

    (Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, Washington 98195, USA)

  • Michael J. Bevan

    (Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, Washington 98195, USA)

Abstract

T-cell activation: mixed affinities According to the prevailing view, high-affinity T-cell receptor (TCR) ligation is required for T-cell priming and thymic negative selection, while low-affinity ligands induce positive selection and lymphopaenia-driven homeostatic expansion. Zehn et al. report that, surprisingly, T-cell expansion after initial activation occurs irrespective of TCR affinity. Low-affinity cells generate functional effector and memory responses. However, their expansion ceases earlier resulting in an overall decreased total number of low-affinity cells compared to their high-affinity counterparts. The findings have implications for autoimmunity and the makeup of the memory T-cell pool.

Suggested Citation

  • Dietmar Zehn & Sarah Y. Lee & Michael J. Bevan, 2009. "Complete but curtailed T-cell response to very low-affinity antigen," Nature, Nature, vol. 458(7235), pages 211-214, March.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7235:d:10.1038_nature07657
    DOI: 10.1038/nature07657
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    Cited by:

    1. Mike B. Barnkob & Yale S. Michaels & Violaine André & Philip S. Macklin & Uzi Gileadi & Salvatore Valvo & Margarida Rei & Corinna Kulicke & Ji-Li Chen & Vitul Jain & Victoria K. Woodcock & Huw Colin-Y, 2024. "Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Alexandria C. Wells & Kaito A. Hioki & Constance C. Angelou & Adam C. Lynch & Xueting Liang & Daniel J. Ryan & Iris Thesmar & Saule Zhanybekova & Saulius Zuklys & Jacob Ullom & Agnes Cheong & Jesse Ma, 2023. "Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Charlotte A. James & Yuexin Xu & Melissa S. Aguilar & Lichen Jing & Erik D. Layton & Martine Gilleron & Adriaan J. Minnaard & Thomas J. Scriba & Cheryl L. Day & Edus H. Warren & David M. Koelle & Chet, 2022. "CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Shu Shien Chin & Erik Guillen & Laurent Chorro & Sooraj Achar & Karina Ng & Susanne Oberle & Francesca Alfei & Dietmar Zehn & Grégoire Altan-Bonnet & Fabien Delahaye & Grégoire Lauvau, 2022. "T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    5. Georg Petkau & Twm J. Mitchell & Krishnendu Chakraborty & Sarah E. Bell & Vanessa D´Angeli & Louise Matheson & David J. Turner & Alexander Saveliev & Ozge Gizlenci & Fiamma Salerno & Peter D. Katsikis, 2022. "The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Lianmei Tan & Tao Yin & Handan Xiang & Liuyang Wang & Poorva Mudgal & Junying Chen & Yi Ding & Guoping Wang & Bryan Jian Wei Lim & Yuqi Huang & De Huang & Yaosi Liang & Peter B. Alexander & Kun Xiang , 2024. "Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    7. Asif A. Dar & Dale D. Kim & Scott M. Gordon & Kathleen Klinzing & Siera Rosen & Ipsita Guha & Nadia Porter & Yohaniz Ortega & Katherine S. Forsyth & Jennifer Roof & Hossein Fazelinia & Lynn A. Spruce , 2023. "c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    8. Lion F. K. Uhl & Han Cai & Sophia L. Oram & Jagdish N. Mahale & Andrew J. MacLean & Julie M. Mazet & Theo Piccirilli & Alexander J. He & Doreen Lau & Tim Elliott & Audrey Gerard, 2023. "Interferon-γ couples CD8+ T cell avidity and differentiation during infection," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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