IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v458y2009i7235d10.1038_nature07657.html
   My bibliography  Save this article

Complete but curtailed T-cell response to very low-affinity antigen

Author

Listed:
  • Dietmar Zehn

    (Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, Washington 98195, USA)

  • Sarah Y. Lee

    (Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, Washington 98195, USA)

  • Michael J. Bevan

    (Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, Washington 98195, USA)

Abstract

T-cell activation: mixed affinities According to the prevailing view, high-affinity T-cell receptor (TCR) ligation is required for T-cell priming and thymic negative selection, while low-affinity ligands induce positive selection and lymphopaenia-driven homeostatic expansion. Zehn et al. report that, surprisingly, T-cell expansion after initial activation occurs irrespective of TCR affinity. Low-affinity cells generate functional effector and memory responses. However, their expansion ceases earlier resulting in an overall decreased total number of low-affinity cells compared to their high-affinity counterparts. The findings have implications for autoimmunity and the makeup of the memory T-cell pool.

Suggested Citation

  • Dietmar Zehn & Sarah Y. Lee & Michael J. Bevan, 2009. "Complete but curtailed T-cell response to very low-affinity antigen," Nature, Nature, vol. 458(7235), pages 211-214, March.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7235:d:10.1038_nature07657
    DOI: 10.1038/nature07657
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07657
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07657?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mike B. Barnkob & Yale S. Michaels & Violaine André & Philip S. Macklin & Uzi Gileadi & Salvatore Valvo & Margarida Rei & Corinna Kulicke & Ji-Li Chen & Vitul Jain & Victoria K. Woodcock & Huw Colin-Y, 2024. "Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Alexandria C. Wells & Kaito A. Hioki & Constance C. Angelou & Adam C. Lynch & Xueting Liang & Daniel J. Ryan & Iris Thesmar & Saule Zhanybekova & Saulius Zuklys & Jacob Ullom & Agnes Cheong & Jesse Ma, 2023. "Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Charlotte A. James & Yuexin Xu & Melissa S. Aguilar & Lichen Jing & Erik D. Layton & Martine Gilleron & Adriaan J. Minnaard & Thomas J. Scriba & Cheryl L. Day & Edus H. Warren & David M. Koelle & Chet, 2022. "CD4 and CD8 co-receptors modulate functional avidity of CD1b-restricted T cells," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Shu Shien Chin & Erik Guillen & Laurent Chorro & Sooraj Achar & Karina Ng & Susanne Oberle & Francesca Alfei & Dietmar Zehn & Grégoire Altan-Bonnet & Fabien Delahaye & Grégoire Lauvau, 2022. "T cell receptor and IL-2 signaling strength control memory CD8+ T cell functional fitness via chromatin remodeling," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    5. Georg Petkau & Twm J. Mitchell & Krishnendu Chakraborty & Sarah E. Bell & Vanessa D´Angeli & Louise Matheson & David J. Turner & Alexander Saveliev & Ozge Gizlenci & Fiamma Salerno & Peter D. Katsikis, 2022. "The timing of differentiation and potency of CD8 effector function is set by RNA binding proteins," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Asif A. Dar & Dale D. Kim & Scott M. Gordon & Kathleen Klinzing & Siera Rosen & Ipsita Guha & Nadia Porter & Yohaniz Ortega & Katherine S. Forsyth & Jennifer Roof & Hossein Fazelinia & Lynn A. Spruce , 2023. "c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    7. Lion F. K. Uhl & Han Cai & Sophia L. Oram & Jagdish N. Mahale & Andrew J. MacLean & Julie M. Mazet & Theo Piccirilli & Alexander J. He & Doreen Lau & Tim Elliott & Audrey Gerard, 2023. "Interferon-γ couples CD8+ T cell avidity and differentiation during infection," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:458:y:2009:i:7235:d:10.1038_nature07657. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.