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Cdc14 inhibits transcription by RNA polymerase I during anaphase

Author

Listed:
  • Andrés Clemente-Blanco

    (Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK)

  • María Mayán-Santos

    (Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK)

  • David A. Schneider

    (University of Alabama at Birmingham, 442 Kaul Human Genetics Building, 720 20th Street South, Birmingham, Alabama 35294, USA)

  • Félix Machín

    (Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK
    Present address: Unidad de Investigación, Hospital Universitario Candelaria, Carretera del Rosario, 38010 Tenerife, Spain.)

  • Adam Jarmuz

    (Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK)

  • Herbert Tschochner

    (Institut für Biochemie, Mikrobiologie und Genetik, Universität Regensburg)

  • Luis Aragón

    (Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College, Du Cane Road, London W12 0NN, UK)

Abstract

Gene silencing in mitosis It has been known for more than 40 years that gene transcription shuts down during cell division. The common explanation for this has been that chromosome condensation limits RNA polymerase activity, but a study in budding yeast suggests that this is not the case. Rather, the conserved phosphatase Cdc14, a mitotic regulator required for nucleolar segregation and mitotic exit, causes gene silencing by preventing the localization of RNA polymerase I (Pol I) to ribosomal DNA during anaphase. If ribosomal transcription is not shut down, the presence of transcripts prevents the loading of condensin and blocks chromosome condensation and segregation.

Suggested Citation

  • Andrés Clemente-Blanco & María Mayán-Santos & David A. Schneider & Félix Machín & Adam Jarmuz & Herbert Tschochner & Luis Aragón, 2009. "Cdc14 inhibits transcription by RNA polymerase I during anaphase," Nature, Nature, vol. 458(7235), pages 219-222, March.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7235:d:10.1038_nature07652
    DOI: 10.1038/nature07652
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    Cited by:

    1. Adrián Campos & Facundo Ramos & Lydia Iglesias & Celia Delgado & Eva Merino & Antonio Esperilla-Muñoz & Jaime Correa-Bordes & Andrés Clemente-Blanco, 2023. "Cdc14 phosphatase counteracts Cdk-dependent Dna2 phosphorylation to inhibit resection during recombinational DNA repair," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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