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Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens

Author

Listed:
  • Sophie Brinster

    (Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France
    INSERM, U567, Paris, France)

  • Gilles Lamberet

    (INRA, UR888, Unité Bactéries Lactiques et Pathogènes Opportunistes, F-78350, Jouy en Josas, France)

  • Bart Staels

    (Institut Pasteur de Lille, INSERM UMR545, Université Lille 2)

  • Patrick Trieu-Cuot

    (Institut Pasteur, Unité de Biologie des Bactéries Pathogènes à Gram Positif, URA CNRS 2172, Paris, France)

  • Alexandra Gruss

    (INRA, UR888, Unité Bactéries Lactiques et Pathogènes Opportunistes, F-78350, Jouy en Josas, France)

  • Claire Poyart

    (Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France
    INSERM, U567, Paris, France
    Institut Pasteur, Unité de Biologie des Bactéries Pathogènes à Gram Positif, URA CNRS 2172, Paris, France
    Assistance Publique Hôpitaux de Paris, Centre National de Référence des Streptocoques, Hôpital Cochin)

Abstract

Antibiotic target missed? The type II fatty acid synthesis (FASII) pathway has been suggested to be a promising antimicrobial target, and the antibiotics platensimycin and platencin that target this pathway are claimed to be potentially effective against multiresistant Gram-positive bacteria. But a new study casts doubt on the value of this approach. Clinical isolates of a series of Gram-positive pathogens, including staphylococci, streptococci, pneumococci, and enterococci, are shown to overcome drug-induced blockade of FASII pathway inhibition when supplied with exogenous fatty acids either in laboratory growth medium or when infecting animals. Importantly, human serum is a highly effective source of fatty acids.

Suggested Citation

  • Sophie Brinster & Gilles Lamberet & Bart Staels & Patrick Trieu-Cuot & Alexandra Gruss & Claire Poyart, 2009. "Type II fatty acid synthesis is not a suitable antibiotic target for Gram-positive pathogens," Nature, Nature, vol. 458(7234), pages 83-86, March.
    • Handle: RePEc:nat:nature:v:458:y:2009:i:7234:d:10.1038_nature07772
    DOI: 10.1038/nature07772
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    Cited by:

    1. Apilaasha Tharmasothirajan & Josef Melcr & John Linney & Thomas Gensch & Karin Krumbach & Karla Marlen Ernst & Christopher Brasnett & Paola Poggi & Andrew R. Pitt & Alan D. Goddard & Alexandros Chatgi, 2023. "Membrane manipulation by free fatty acids improves microbial plant polyphenol synthesis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Clara Lambert & Marine Gaillard & Paprapach Wongdontree & Caroline Bachmann & Antoine Hautcoeur & Karine Gloux & Thomas Guilbert & Celine Méhats & Bastien Prost & Audrey Solgadi & Sonia Abreu & Muriel, 2024. "The double-edged role of FASII regulator FabT in Streptococcus pyogenes infection," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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