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Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

Author

Listed:
  • Juha Laurén

    (Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, Connecticut 06536, USA)

  • David A. Gimbel

    (Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, Connecticut 06536, USA)

  • Haakon B. Nygaard

    (Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, Connecticut 06536, USA)

  • John W. Gilbert

    (Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, Connecticut 06536, USA)

  • Stephen M. Strittmatter

    (Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, Connecticut 06536, USA)

Abstract

Prion link to Alzheimer's The hypothesis that soluble amyloid-β peptide oligomer plays a central role in Alzheimer's disease is well established, yet no mechanistic basis for Aβ oligomer effects on neurons has been described. Several lines of evidence point to the existence of a high-affinity cell-surface receptor for soluble Aβ oligomers on neurons as central to Alzheimer's disease pathology and now cellular prion protein PrPC has been identified as a candidate for that role. PrP, a plasma membrane glycoprotein associated with lipid rafts, binds Aβ oligomers selectively with high affinity and mediates the deleterious effects of the peptide. These data raise the possibility that PrPC-specific drugs might have therapeutic potential in Alzheimer's, and point to an unexpected link between infectious prion diseases and Alzheimer's disease.

Suggested Citation

  • Juha Laurén & David A. Gimbel & Haakon B. Nygaard & John W. Gilbert & Stephen M. Strittmatter, 2009. "Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers," Nature, Nature, vol. 457(7233), pages 1128-1132, February.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7233:d:10.1038_nature07761
    DOI: 10.1038/nature07761
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    Cited by:

    1. Li, Huixia & Zhao, Hongyong, 2022. "Mathematical model of Alzheimer’s disease with prion proteins interactions and treatment," Applied Mathematics and Computation, Elsevier, vol. 433(C).

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