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Artificial nanopores that mimic the transport selectivity of the nuclear pore complex

Author

Listed:
  • Tijana Jovanovic-Talisman

    (Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, and,)

  • Jaclyn Tetenbaum-Novatt

    (Laboratory of Cellular and Structural Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA)

  • Anna Sophia McKenney

    (Laboratory of Cellular and Structural Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA)

  • Anton Zilman

    (Theoretical Biology and Biophysics Group and Center for Nonlinear Studies, Los Alamos National Laboratory, PO Box 1663, Los Alamos, New Mexico 87545, USA)

  • Reiner Peters

    (Institute of Medical Physics and Biophysics and Center of Nanotechnology (CeNTech), University of Muenster, Robert-Koch-Strasse 31, 48149 Muenster, Germany)

  • Michael P. Rout

    (Laboratory of Cellular and Structural Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10065, USA)

  • Brian T. Chait

    (Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, and,)

Abstract

Artificial nanopores: across the nuclear barrier Nuclear pore complexes (NPCs) are the gateways between a cell's nucleus and its cytoplasm and allow only selected macromolecules to cross the nuclear envelope. Based on an elucidation of the architecture and mechanism of this complex, Jovanovic-Talisman et al. have designed and produced an artificial nanopore membrane that mimics its selectivity. The membrane features the two vital elements of the natural complex - a simple passageway and a lining of proteins, phenylalanine-glycine nucleoporins, familiarly known as 'FG-nups'. As in the natural complex, the artificial nanopores allow only transport factors and transport-factor-carrying cargoes that specifically bind to FG-nups, to pass. This work opens the way to an array of nature-inspired nanodevices that can detect and sort molecules of medical and industrial significance.

Suggested Citation

  • Tijana Jovanovic-Talisman & Jaclyn Tetenbaum-Novatt & Anna Sophia McKenney & Anton Zilman & Reiner Peters & Michael P. Rout & Brian T. Chait, 2009. "Artificial nanopores that mimic the transport selectivity of the nuclear pore complex," Nature, Nature, vol. 457(7232), pages 1023-1027, February.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7232:d:10.1038_nature07600
    DOI: 10.1038/nature07600
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    Cited by:

    1. Ruhollah Moussavi-Baygi & Yousef Jamali & Reza Karimi & Mohammad R K Mofrad, 2011. "Brownian Dynamics Simulation of Nucleocytoplasmic Transport: A Coarse-Grained Model for the Functional State of the Nuclear Pore Complex," PLOS Computational Biology, Public Library of Science, vol. 7(6), pages 1-16, June.

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