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Calcium flickers steer cell migration

Author

Listed:
  • Chaoliang Wei

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Xianhua Wang

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Min Chen

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Kunfu Ouyang

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Long-Sheng Song

    (University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA)

  • Heping Cheng

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

Abstract

Calcium leads the way Directional cell movement depends on an intracellular calcium gradient. In a study of migrating fibroblasts, Chaoliang Wei et al. have identified calcium flickers — high-calcium microdomains — as part of the mechanism that steers cells to their targets. The flickers are most active at the leading edge of migrating cells. In the presence of a chemotactic gradient, an asymmetric gradient of calcium flicker activity develops which promotes turning of cells towards the direction of the chemoattractant.

Suggested Citation

  • Chaoliang Wei & Xianhua Wang & Min Chen & Kunfu Ouyang & Long-Sheng Song & Heping Cheng, 2009. "Calcium flickers steer cell migration," Nature, Nature, vol. 457(7231), pages 901-905, February.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7231:d:10.1038_nature07577
    DOI: 10.1038/nature07577
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    Cited by:

    1. Taeseok Daniel Yang & Jin-Sung Park & Youngwoon Choi & Wonshik Choi & Tae-Wook Ko & Kyoung J Lee, 2011. "Zigzag Turning Preference of Freely Crawling Cells," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-9, June.
    2. Martina Nicoletti & Letizia Chiodo & Alessandro Loppini, 2021. "Biophysics and Modeling of Mechanotransduction in Neurons: A Review," Mathematics, MDPI, vol. 9(4), pages 1-32, February.

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