IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v457y2009i7231d10.1038_nature07577.html
   My bibliography  Save this article

Calcium flickers steer cell migration

Author

Listed:
  • Chaoliang Wei

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Xianhua Wang

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Min Chen

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Kunfu Ouyang

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

  • Long-Sheng Song

    (University of Iowa Carver College of Medicine, Iowa City, Iowa 52242, USA)

  • Heping Cheng

    (Institute of Molecular Medicine, State Key Laboratory of Biomembrane and Membrane Biotechnology, Peking University)

Abstract

Calcium leads the way Directional cell movement depends on an intracellular calcium gradient. In a study of migrating fibroblasts, Chaoliang Wei et al. have identified calcium flickers — high-calcium microdomains — as part of the mechanism that steers cells to their targets. The flickers are most active at the leading edge of migrating cells. In the presence of a chemotactic gradient, an asymmetric gradient of calcium flicker activity develops which promotes turning of cells towards the direction of the chemoattractant.

Suggested Citation

  • Chaoliang Wei & Xianhua Wang & Min Chen & Kunfu Ouyang & Long-Sheng Song & Heping Cheng, 2009. "Calcium flickers steer cell migration," Nature, Nature, vol. 457(7231), pages 901-905, February.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7231:d:10.1038_nature07577
    DOI: 10.1038/nature07577
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07577
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07577?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Martina Nicoletti & Letizia Chiodo & Alessandro Loppini, 2021. "Biophysics and Modeling of Mechanotransduction in Neurons: A Review," Mathematics, MDPI, vol. 9(4), pages 1-32, February.
    2. Taeseok Daniel Yang & Jin-Sung Park & Youngwoon Choi & Wonshik Choi & Tae-Wook Ko & Kyoung J Lee, 2011. "Zigzag Turning Preference of Freely Crawling Cells," PLOS ONE, Public Library of Science, vol. 6(6), pages 1-9, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:457:y:2009:i:7231:d:10.1038_nature07577. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.