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Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans

Author

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  • Sakiko Honjoh

    (Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan)

  • Takuya Yamamoto

    (Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan)

  • Masaharu Uno

    (Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan)

  • Eisuke Nishida

    (Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto, 606-8502, Japan)

Abstract

Fasting for longevity Dietary restriction can extend lifespan in various species. In mammals, intermittent fasting can also extend lifespan and reduce the incidence of age-related disorders, even when there is little or no decrease in calorie intake. In a study of the molecular mechanisms associated with the beneficial effect of intermittent fasting, Honjoh et al. established a fasting regime that extends the lifespan of Caenorhabditis elegans, and show that the low molecular weight GTPase RHEB-1 has a dual role in lifespan regulation. It is required for the intermittent fasting-induced longevity, whereas RHEB-1 inhibition mimics the effects of caloric restriction. RHEB-1 exerts its effects in intermittent fasting in part via the insulin/insulin growth factor-like signalling effector DAF-16. These findings may contribute to the development of dietary restriction mimetics intended to improve health without toxic side effects.

Suggested Citation

  • Sakiko Honjoh & Takuya Yamamoto & Masaharu Uno & Eisuke Nishida, 2009. "Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans," Nature, Nature, vol. 457(7230), pages 726-730, February.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7230:d:10.1038_nature07583
    DOI: 10.1038/nature07583
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    Cited by:

    1. Jae-Seong Yang & Hyun-Jun Nam & Mihwa Seo & Seong Kyu Han & Yonghwan Choi & Hong Gil Nam & Seung-Jae Lee & Sanguk Kim, 2011. "OASIS: Online Application for the Survival Analysis of Lifespan Assays Performed in Aging Research," PLOS ONE, Public Library of Science, vol. 6(8), pages 1-11, August.

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