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Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

Author

Listed:
  • Aurelien Trompette

    (Division of Molecular Immunology,)

  • Senad Divanovic

    (Division of Molecular Immunology,)

  • Alberto Visintin

    (University of Massachusetts Medical School, Worcester, Massachusetts 01606, USA)

  • Carine Blanchard

    (Division of Allergy and Immunology,)

  • Rashmi S. Hegde

    (and)

  • Rajat Madan

    (Division of Molecular Immunology,)

  • Peter S. Thorne

    (and)

  • Marsha Wills-Karp

    (Cincinnati Children’s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA)

  • Theresa L. Gioannini

    (Inflammation Program, University of Iowa, Iowa City, Iowa 52241, USA
    Veteran’s Affairs Medical Center, Iowa City, Iowa 52247, USA)

  • Jerry P. Weiss

    (Inflammation Program, University of Iowa, Iowa City, Iowa 52241, USA
    Veteran’s Affairs Medical Center, Iowa City, Iowa 52247, USA)

  • Christopher L. Karp

    (Division of Molecular Immunology,)

Abstract

Mite allergen plays tricks House dust mites (Dermatophagoides spp.) are a common cause of allergy, known to trigger asthma attacks. The main dust-mite allergen, Der p 2, is found in high concentrations in mite faecal pellets. Der p 2 has structural homology with a component of the Toll-like-receptor signalling complex, and now that homology has been implicated in the mechanism by which such a strong allergic response is provoked. Der p 2 is shown to mimic the function of a Toll-like receptor complex protein, acting as an 'auto-adjuvant' and in effect tricking the immune system into believing that it is facing a bacterial infection.

Suggested Citation

  • Aurelien Trompette & Senad Divanovic & Alberto Visintin & Carine Blanchard & Rashmi S. Hegde & Rajat Madan & Peter S. Thorne & Marsha Wills-Karp & Theresa L. Gioannini & Jerry P. Weiss & Christopher L, 2009. "Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein," Nature, Nature, vol. 457(7229), pages 585-588, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7229:d:10.1038_nature07548
    DOI: 10.1038/nature07548
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    Cited by:

    1. Unnur S Bjornsdottir & Stephen T Holgate & Padmalatha S Reddy & Andrew A Hill & Charlotte M McKee & Cristina I Csimma & Amy A Weaver & Holly M Legault & Clayton G Small & Renee C Ramsey & Debra K Elli, 2011. "Pathways Activated during Human Asthma Exacerbation as Revealed by Gene Expression Patterns in Blood," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-19, July.

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