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Protein kinase R reveals an evolutionary model for defeating viral mimicry

Author

Listed:
  • Nels C. Elde

    (Division of Basic Sciences,)

  • Stephanie J. Child

    (and)

  • Adam P. Geballe

    (and
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    University of Washington, Seattle, Washington 98115, USA)

  • Harmit S. Malik

    (Division of Basic Sciences,)

Abstract

Virus versus innate immunity Poxviruses, such as small pox, undermine host defences by producing a protein called K3L, which closely mimics the substrate of protein kinase R (PKR), an important component of the vertebrate innate immunity system. Elde et al. show that PKR evolved under dramatic episodes of positive selection in primates, substituting amino acids at sites where K3L and PKR meet. The evolutionary changes increase the chances of the host defeating the mimic and see the two protagonists locked in a molecular 'arms race' trying to out-smart and out-evolve each other.

Suggested Citation

  • Nels C. Elde & Stephanie J. Child & Adam P. Geballe & Harmit S. Malik, 2009. "Protein kinase R reveals an evolutionary model for defeating viral mimicry," Nature, Nature, vol. 457(7228), pages 485-489, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7228:d:10.1038_nature07529
    DOI: 10.1038/nature07529
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    Cited by:

    1. Joseph Hiatt & Judd F. Hultquist & Michael J. McGregor & Mehdi Bouhaddou & Ryan T. Leenay & Lacy M. Simons & Janet M. Young & Paige Haas & Theodore L. Roth & Victoria Tobin & Jason A. Wojcechowskyj & , 2022. "A functional map of HIV-host interactions in primary human T cells," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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