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Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

Author

Listed:
  • Patrick Narbonne

    (McGill University, Montréal, Québec H3A 1B1, Canada)

  • Richard Roy

    (McGill University, Montréal, Québec H3A 1B1, Canada)

Abstract

Burning off the fat To survive in a harsh environment, larvae of the Caenorhabditis elegans roundworm can enter a 'dauer' state during which they don't eat, but remain active and become stress-resistant and extremely long-lived. A typical dauer has reduced insulin-like signalling, full nutrient stores and global changes in its metabolism. Patrick Narbonne and Richard Roy show that without AMPK (LKB1) signalling, dauers rapidly consume their stored energy and expire prematurely due to vital organ failure. In a normal dauer larva, LKB1/AMPK ensures a long and active life without the need for food by slowing down triglyceride hydrolysis so that the fat reserves last and proper osmoregulation is maintained. This work touches on systems involved in research on ageing, diabetes and obesity.

Suggested Citation

  • Patrick Narbonne & Richard Roy, 2009. "Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival," Nature, Nature, vol. 457(7226), pages 210-214, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7226:d:10.1038_nature07536
    DOI: 10.1038/nature07536
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    Cited by:

    1. Caroline Beaudoin-Chabot & Lei Wang & Cenk Celik & Aishah Tul-Firdaus Abdul Khalid & Subhash Thalappilly & Shiyi Xu & Jhee Hong Koh & Venus Wen Xuan Lim & Ann Don Low & Guillaume Thibault, 2022. "The unfolded protein response reverses the effects of glucose on lifespan in chemically-sterilized C. elegans," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    2. Elite Possik & Laura-Lee Klein & Perla Sanjab & Ruyuan Zhu & Laurence Côté & Ying Bai & Dongwei Zhang & Howard Sun & Anfal Al-Mass & Abel Oppong & Rasheed Ahmad & Alex Parker & S.R. Murthy Madiraju & , 2023. "Glycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Samim Sharifi & Prerana Chaudhari & Asya Martirosyan & Alexander Otto Eberhardt & Finja Witt & André Gollowitzer & Lisa Lange & Yvonne Woitzat & Eberechukwu Maryann Okoli & Huahui Li & Norman Rahnis &, 2024. "Reducing the metabolic burden of rRNA synthesis promotes healthy longevity in Caenorhabditis elegans," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Jin-Hyuck Jeong & Jun-Seok Han & Youngae Jung & Seung-Min Lee & So-Hyun Park & Mooncheol Park & Min-Gi Shin & Nami Kim & Mi Sun Kang & Seokho Kim & Kwang-Pyo Lee & Ki-Sun Kwon & Chun-A. Kim & Yong Ryo, 2023. "A new AMPK isoform mediates glucose-restriction induced longevity non-cell autonomously by promoting membrane fluidity," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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