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The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear

Author

Listed:
  • Jessica R. Colantonio

    (Immunology and Molecular Genetics)

  • Julien Vermot

    (Biological Imaging Center, Beckman Institute, California Institute of Technology, Pasadena, California 91125, USA)

  • David Wu

    (Biological Imaging Center, Beckman Institute, California Institute of Technology, Pasadena, California 91125, USA)

  • Adam D. Langenbacher

    (Cell, and Developmental Biology)

  • Scott Fraser

    (Biological Imaging Center, Beckman Institute, California Institute of Technology, Pasadena, California 91125, USA)

  • Jau-Nian Chen

    (Cell, and Developmental Biology
    Molecular Biology Institute, University of California, Los Angeles, California 90095, USA)

  • Kent L. Hill

    (Immunology and Molecular Genetics
    Molecular Biology Institute, University of California, Los Angeles, California 90095, USA)

Abstract

Cilia strike a balance In zebrafish — as in humans and other vertebrates — hearing and balance are mediated by mechanical sensors in the inner ear. These sensors consist of biomineralized composite crystals, called otoliths. Colantonio et al. use in vivo video microscopy of zebrafish embryos to show that fluid flow generated by cilia influences the number, growth and localization of otoliths, as well as their mineralization during development. Gene-knockdown with 'morpholino' antisense oligonucleotides shows that the dynein regulatory complex is required for cilium motility. Thus cilia-driven flow appears to be a key epigenetic factor in controlling otolith biomineralization, and dynein regulatory complex subunits emerge as candidates for disease genes for ciliopathies in humans.

Suggested Citation

  • Jessica R. Colantonio & Julien Vermot & David Wu & Adam D. Langenbacher & Scott Fraser & Jau-Nian Chen & Kent L. Hill, 2009. "The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear," Nature, Nature, vol. 457(7226), pages 205-209, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7226:d:10.1038_nature07520
    DOI: 10.1038/nature07520
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    Cited by:

    1. Zhijun Dong & Fanghan Wang & Yali Liu & Yongxue Li & Haiyan Yu & Saijun Peng & Tingting Sun & Meng Qu & Ke Sun & Lei Wang & Yuanqing Ma & Kai Chen & Jianmin Zhao & Qiang Lin, 2024. "Genomic and single-cell analyses reveal genetic signatures of swimming pattern and diapause strategy in jellyfish," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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