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Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis

Author

Listed:
  • Sunhwa Kim

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA)

  • Hiroyuki Takahashi

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA)

  • Wan-Wan Lin

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA
    College of Medicine, National Taiwan University)

  • Pascal Descargues

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA)

  • Sergei Grivennikov

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA)

  • Youngjun Kim

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA
    Present addresses: Department of Applied Biochemistry, Konkuk University, 322 Danwol-dong, Chungju-City, Chungbuk 380-701, Korea (Y.K.); Department of Cancer Biology, The Scripps Research Institute, 5353 Parkside Drive, Jupiter, Florida 33458, USA (J.-L.L.).)

  • Jun-Li Luo

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA
    Present addresses: Department of Applied Biochemistry, Konkuk University, 322 Danwol-dong, Chungju-City, Chungbuk 380-701, Korea (Y.K.); Department of Cancer Biology, The Scripps Research Institute, 5353 Parkside Drive, Jupiter, Florida 33458, USA (J.-L.L.).)

  • Michael Karin

    (School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0723, USA)

Abstract

Versican drives metastasis Distant-site metastases are the leading cause of cancer-associated mortality. A study of the inflammatory microenvironment of cancer cells has identified versican, an extracellular matrix proteoglycan, as a possible factor in driving metastasis. It was isolated from the highly metastatic Lewis lung carcinoma cells as a potent inducer of macrophage activation. Versican, which is upregulated in many human tumours, stimulates bone marrow cells via the Toll-like receptor TLR2 to produce the inflammatory protein TNF-?, which enhances the spread of metastases. This points to versican and the other components of this signalling pathway as potential targets for antimetastatic intervention.

Suggested Citation

  • Sunhwa Kim & Hiroyuki Takahashi & Wan-Wan Lin & Pascal Descargues & Sergei Grivennikov & Youngjun Kim & Jun-Li Luo & Michael Karin, 2009. "Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis," Nature, Nature, vol. 457(7225), pages 102-106, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7225:d:10.1038_nature07623
    DOI: 10.1038/nature07623
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    Cited by:

    1. Zhang, Wang & Pal, Sumanta K. & Liu, Xueli & Yang, Chunmei & Allahabadi, Sachin & Bhanji, Shaira & Figlin, Robert A. & Yu, Hua & Reckamp, Karen L., 2013. "Myeloid Clusters Are Associated with a Pro-Metastatic Environment and Poor Prognosis in Smoking-Related Early Stage Non-Small Cell Lung Cancer," Scholarly Articles 11859328, Harvard University Department of Economics.
    2. Paul K. Paik & Jia Luo & Ni Ai & Rachel Kim & Linda Ahn & Anup Biswas & Courtney Coker & Wanchao Ma & Phillip Wong & Darren J. Buonocore & W. Victoria Lai & Jamie E. Chaft & Swarnali Acharyya & Joan M, 2022. "Phase I trial of the TNF-α inhibitor certolizumab plus chemotherapy in stage IV lung adenocarcinomas," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    3. Zhiyuan Zheng & Ya-nan Li & Shanfen Jia & Mengting Zhu & Lijuan Cao & Min Tao & Jingting Jiang & Shenghua Zhan & Yongjing Chen & Ping-Jin Gao & Weiguo Hu & Ying Wang & Changshun Shao & Yufang Shi, 2021. "Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3," Nature Communications, Nature, vol. 12(1), pages 1-15, December.
    4. Samira Ghorbani & Emily Jelinek & Rajiv Jain & Benjamin Buehner & Cenxiao Li & Brian M. Lozinski & Susobhan Sarkar & Deepak K. Kaushik & Yifei Dong & Thomas N. Wight & Soheila Karimi-Abdolrezaee & Gee, 2022. "Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    5. Samuel Kwaku Agyei & Godwin Adolf Idan, 2022. "Trade Openness, Institutions, and Inclusive Growth in Sub-Saharan Africa," SAGE Open, , vol. 12(2), pages 21582440221, May.

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