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Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys

Author

Listed:
  • Jinyan Liu

    (Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Kara L. O’Brien

    (Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Diana M. Lynch

    (Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Nathaniel L. Simmons

    (Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Annalena La Porte

    (Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Ambryice M. Riggs

    (Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Peter Abbink

    (Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Rory T. Coffey

    (Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Lauren E. Grandpre

    (Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Michael S. Seaman

    (Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

  • Gary Landucci

    (University of California, Irvine School of Medicine, Irvine, California 92697, USA)

  • Donald N. Forthal

    (University of California, Irvine School of Medicine, Irvine, California 92697, USA)

  • David C. Montefiori

    (Duke University Medical Center, Durham, North Carolina 27710, USA)

  • Angela Carville

    (New England Primate Research Center, Southborough, Massachusetts 01772, USA)

  • Keith G. Mansfield

    (New England Primate Research Center, Southborough, Massachusetts 01772, USA)

  • Menzo J. Havenga

    (TNO Biosciences, 2301 CE, Leiden, The Netherlands)

  • Maria G. Pau

    (Crucell Holland BV, 2301 CA, Leiden, The Netherlands)

  • Jaap Goudsmit

    (Crucell Holland BV, 2301 CA, Leiden, The Netherlands)

  • Dan H. Barouch

    (Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

Abstract

AIDS vaccine rethink Recent setbacks have prompted a major re-evaluation of the AIDS vaccine field. One question that has been asked is whether to continue development of T-cell-based HIV-1 vaccines. Now a study of a new vaccine in monkeys challenged with simian immunodeficiency virus (SIV) suggests that the T-cell-based strategy remains potentially viable. The vaccine was prepared using two adenovirus vectors (rAd26 prime/rAd5 boost) expressing SIV Gag protein. It induced potent T-cell immune responses and some protection from infection. These findings provide pointers to the design of a new generation of T-cell-based vaccine candidates for HIV-1.

Suggested Citation

  • Jinyan Liu & Kara L. O’Brien & Diana M. Lynch & Nathaniel L. Simmons & Annalena La Porte & Ambryice M. Riggs & Peter Abbink & Rory T. Coffey & Lauren E. Grandpre & Michael S. Seaman & Gary Landucci & , 2009. "Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys," Nature, Nature, vol. 457(7225), pages 87-91, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7225:d:10.1038_nature07469
    DOI: 10.1038/nature07469
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    Cited by:

    1. Vitaly V Ganusov & Daniel L Barber & Rob J De Boer, 2011. "Killing of Targets by CD8+ T Cells in the Mouse Spleen Follows the Law of Mass Action," PLOS ONE, Public Library of Science, vol. 6(1), pages 1-8, January.

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