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Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche

Author

Listed:
  • Cristina Lo Celso

    (Center for Regenerative Medicine and,
    Harvard Stem Cell Institute, 42 Church Street, Cambridge, Massachusetts 02138, USA)

  • Heather E. Fleming

    (Center for Regenerative Medicine and,
    Harvard Stem Cell Institute, 42 Church Street, Cambridge, Massachusetts 02138, USA)

  • Juwell W. Wu

    (Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Harvard Stem Cell Institute, 42 Church Street, Cambridge, Massachusetts 02138, USA)

  • Cher X. Zhao

    (Center for Regenerative Medicine and,
    Harvard Stem Cell Institute, 42 Church Street, Cambridge, Massachusetts 02138, USA)

  • Sam Miake-Lye

    (Center for Regenerative Medicine and,)

  • Joji Fujisaki

    (Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Harvard Stem Cell Institute, 42 Church Street, Cambridge, Massachusetts 02138, USA)

  • Daniel Côté

    (Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Present address: Centre de Recherche Université Laval Robert-Giffard, Département de Physique, Université Laval, Québec, Québec G1J 2G3, Canada.)

  • David W. Rowe

    (University of Connecticut Health Center, 663 Farmington Avenue, Farmington, Connecticut 06030, USA)

  • Charles P. Lin

    (Advanced Microscopy Program, Center for Systems Biology and Wellman Center for Photomedicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, Massachusetts 02114, USA
    Harvard Stem Cell Institute, 42 Church Street, Cambridge, Massachusetts 02138, USA)

  • David T. Scadden

    (Center for Regenerative Medicine and,
    Cancer Center,
    Harvard Stem Cell Institute, 42 Church Street, Cambridge, Massachusetts 02138, USA
    Harvard University, 42 Church Street, Cambridge, Massachusetts 02138, USA)

Abstract

A bone-marrow niche Haematopoietic stem cells are found in a specialized regulatory environment or niche in bone marrow. The precise location and characteristics of this niche are now made clearer by two sophisticated imaging studies. Lo Celso et al. performed live-animal tracking of individual haematopoietic cells and find that osteoblasts are enmeshed in microvessels and that different haematopoietic cell populations are localized in different areas according to their stage of differentiation. Xie et al. used newly developed ex vivo real-time imaging technology and immunoassays to trace the homing of fluorescently labelled haematopoietic stem cells in response to irradiation. They report that the membrane lining the medullary cavity of bone forms a special zone that normally maintains haematopoietic stem cells, but promotes their expansion in response to bone marrow damage.

Suggested Citation

  • Cristina Lo Celso & Heather E. Fleming & Juwell W. Wu & Cher X. Zhao & Sam Miake-Lye & Joji Fujisaki & Daniel Côté & David W. Rowe & Charles P. Lin & David T. Scadden, 2009. "Live-animal tracking of individual haematopoietic stem/progenitor cells in their niche," Nature, Nature, vol. 457(7225), pages 92-96, January.
    • Handle: RePEc:nat:nature:v:457:y:2009:i:7225:d:10.1038_nature07434
    DOI: 10.1038/nature07434
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    Cited by:

    1. Alexandra N. Rindone & Xiaonan Liu & Stephanie Farhat & Alexander Perdomo-Pantoja & Timothy F. Witham & Daniel L. Coutu & Mei Wan & Warren L. Grayson, 2021. "Quantitative 3D imaging of the cranial microvascular environment at single-cell resolution," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. M. Gabriele Bixel & Kishor K. Sivaraj & Melanie Timmen & Vishal Mohanakrishnan & Anusha Aravamudhan & Susanne Adams & Bong-Ihn Koh & Hyun-Woo Jeong & Kai Kruse & Richard Stange & Ralf H. Adams, 2024. "Angiogenesis is uncoupled from osteogenesis during calvarial bone regeneration," Nature Communications, Nature, vol. 15(1), pages 1-22, December.
    3. Runfeng Miao & Harim Chun & Xing Feng & Ana Cordeiro Gomes & Jungmin Choi & João P. Pereira, 2022. "Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Qiang Zhao & Young-Min Han & Ping Song & Zhixue Liu & Zuyi Yuan & Ming-Hui Zou, 2022. "Endothelial cell-specific expression of serine/threonine kinase 11 modulates dendritic cell differentiation," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    5. Yang Liu & Qi Chen & Hyun-Woo Jeong & Bong Ihn Koh & Emma C. Watson & Cong Xu & Martin Stehling & Bin Zhou & Ralf H. Adams, 2022. "A specialized bone marrow microenvironment for fetal haematopoiesis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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