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A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex

Author

Listed:
  • Bernard T. Kelly

    (University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0XY, UK)

  • Airlie J. McCoy

    (University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0XY, UK)

  • Kira Späte

    (Institute of Biochemistry I and Center for Molecular Medicine Cologne, University of Cologne, Joseph-Stelzmann-Strasse 52, 50931 Cologne, Germany
    Present address: Max Planck Institute for Experimental Medicine, Hermann-Rein-Strasse 3, 37075 Göttingen, Germany.)

  • Sharon E. Miller

    (University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0XY, UK)

  • Philip R. Evans

    (Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK)

  • Stefan Höning

    (Institute of Biochemistry I and Center for Molecular Medicine Cologne, University of Cologne, Joseph-Stelzmann-Strasse 52, 50931 Cologne, Germany)

  • David J. Owen

    (University of Cambridge, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 0XY, UK)

Abstract

AP2 clathrin adaptor: target recognition unveiled The movement of most transmembrane proteins between the various membranes of the cell is directed by short linear amino acid sequences in their cytoplasmic portions. These sequence motifs are bound by protein components of transport vesicle coats thereby incorporating the transmembrane proteins as vesicle cargo. In the case of clathrin-coated vesicles (CCVs) the motifs are recognised by the AP complexes or GGA clathrin adaptors. The clathrin adaptor AP2 recognizes two major classes of endocytic motifs including an acidic dileucine motif. In this study, Kelly et al. present the crystal structure of AP2 in a complex with the dileucine motif of a cargo protein thereby revealing the mechanism of cargo-adaptor recognition.

Suggested Citation

  • Bernard T. Kelly & Airlie J. McCoy & Kira Späte & Sharon E. Miller & Philip R. Evans & Stefan Höning & David J. Owen, 2008. "A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex," Nature, Nature, vol. 456(7224), pages 976-979, December.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7224:d:10.1038_nature07422
    DOI: 10.1038/nature07422
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    Cited by:

    1. Hideaki T. Matsubayashi & Jack Mountain & Nozomi Takahashi & Abhijit Deb Roy & Tony Yao & Amy F. Peterson & Cristian Saez Gonzalez & Ibuki Kawamata & Takanari Inoue, 2024. "Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP2-mediated endocytosis," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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