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DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes

Author

Listed:
  • Andrea L. Bredemeyer

    (Washington University School of Medicine, St. Louis, Missouri 63110, USA)

  • Beth A. Helmink

    (Washington University School of Medicine, St. Louis, Missouri 63110, USA)

  • Cynthia L. Innes

    (Environmental Stress and Cancer Group, and NIEHS Microarray Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA)

  • Boris Calderon

    (Washington University School of Medicine, St. Louis, Missouri 63110, USA)

  • Lisa M. McGinnis

    (Washington University School of Medicine, St. Louis, Missouri 63110, USA)

  • Grace K. Mahowald

    (Washington University School of Medicine, St. Louis, Missouri 63110, USA)

  • Eric J. Gapud

    (Washington University School of Medicine, St. Louis, Missouri 63110, USA)

  • Laura M. Walker

    (Washington University School of Medicine, St. Louis, Missouri 63110, USA)

  • Jennifer B. Collins

    (Environmental Stress and Cancer Group, and NIEHS Microarray Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA)

  • Brian K. Weaver

    (Washington University School of Medicine, St. Louis, Missouri 63110, USA)

  • Laura Mandik-Nayak

    (Washington University School of Medicine, St. Louis, Missouri 63110, USA)

  • Robert D. Schreiber

    (Washington University School of Medicine, St. Louis, Missouri 63110, USA)

  • Paul M. Allen

    (Washington University School of Medicine, St. Louis, Missouri 63110, USA)

  • Michael J. May

    (School of Veterinary Medicine, and,)

  • Richard S. Paules

    (Environmental Stress and Cancer Group, and NIEHS Microarray Group, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA)

  • Craig H. Bassing

    (Center for Childhood Cancer Research, Children’s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Abramson Family Cancer Research Institute, Philadelphia, Philadelphia 19104, USA)

  • Barry P. Sleckman

    (Washington University School of Medicine, St. Louis, Missouri 63110, USA)

Abstract

DNA breaks: there for a purpose As part of the response to exogenous DNA damage, the transcription of certain genes involved in cell cycle checkpoints and survival is affected; these changes help the cell to maintain its genomic integrity. There are also situations in which endogenous, physiological DNA double-strand breaks occur. In this work, Bredemeyer et al. show that the breaks which initiate the rearrangement of antigen receptor genes also activate a transcriptional program — but with a difference. Many of the regulated genes are involved in lymphocyte development. Thus, DNA breaks can regulate cell-type-specific processes and not just functions that will allow the cell to repair and survive a DNA break.

Suggested Citation

  • Andrea L. Bredemeyer & Beth A. Helmink & Cynthia L. Innes & Boris Calderon & Lisa M. McGinnis & Grace K. Mahowald & Eric J. Gapud & Laura M. Walker & Jennifer B. Collins & Brian K. Weaver & Laura Mand, 2008. "DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes," Nature, Nature, vol. 456(7223), pages 819-823, December.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7223:d:10.1038_nature07392
    DOI: 10.1038/nature07392
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    Cited by:

    1. Daipayan Banerjee & Kurt Langberg & Salar Abbas & Eric Odermatt & Praveen Yerramothu & Martin Volaric & Matthew A. Reidenbach & Kathy J. Krentz & C. Dustin Rubinstein & David L. Brautigan & Tarek Abba, 2021. "A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling," Nature Communications, Nature, vol. 12(1), pages 1-24, December.

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