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Role for perinuclear chromosome tethering in maintenance of genome stability

Author

Listed:
  • Karim Mekhail

    (Howard Hughes Medical Institute and,
    Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Jan Seebacher

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Steven P. Gygi

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Danesh Moazed

    (Howard Hughes Medical Institute and,
    Harvard Medical School, Boston, Massachusetts 02115, USA)

Abstract

Chromsomes tethered for stability Suppressing the homologous recombination of repetitive DNA sequences is important for maintaining genome stability, and packaging of repeat DNA into silent chromatin was generally thought to protect it from recombination. Here, yeast ribosomal DNA (rDNA) repetitive sequences are shown to associate with the nuclear periphery via inner nuclear membrane proteins, and this tethering is required for rDNA stability. Sir2-dependent silencing is not sufficient to inhibit rDNA recombination. The inner nuclear membrane proteins involved are conserved and have been implicated in chromosome organization in metazoans. These results therefore reveal an ancient mechanism in which interactions between inner nuclear membrane proteins and chromosomal proteins ensure genome stability.

Suggested Citation

  • Karim Mekhail & Jan Seebacher & Steven P. Gygi & Danesh Moazed, 2008. "Role for perinuclear chromosome tethering in maintenance of genome stability," Nature, Nature, vol. 456(7222), pages 667-670, December.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7222:d:10.1038_nature07460
    DOI: 10.1038/nature07460
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    Cited by:

    1. Negin Khosraviani & V. Talya Yerlici & Jonathan St-Germain & Yi Yang Hou & Shi Bo Cao & Carla Ghali & Michael Bokros & Rehna Krishnan & Razqallah Hakem & Stephen Lee & Brian Raught & Karim Mekhail, 2024. "Nucleolar Pol II interactome reveals TBPL1, PAF1, and Pol I at intergenic rDNA drive rRNA biogenesis," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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