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A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

Author

Listed:
  • Yi Liu

    (The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, California 92037, USA)

  • Renaud Dentin

    (The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, California 92037, USA)

  • Danica Chen

    (Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

  • Susan Hedrick

    (The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, California 92037, USA)

  • Kim Ravnskjaer

    (The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, California 92037, USA)

  • Simon Schenk

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Jill Milne

    (Sirtris Pharmaceuticals Inc., 200 Technology Square, Cambridge, Massachusetts 02139, USA)

  • David J. Meyers

    (Johns Hopkins University School of Medicine, 725 North Wolfe Street, 316 Hunterian Building, Baltimore, Maryland 21205, USA)

  • Phil Cole

    (Johns Hopkins University School of Medicine, 725 North Wolfe Street, 316 Hunterian Building, Baltimore, Maryland 21205, USA)

  • John Yates III

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Jerrold Olefsky

    (University of California, San Diego, La Jolla, California 92093, USA)

  • Leonard Guarente

    (Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA)

  • Marc Montminy

    (The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, California 92037, USA)

Abstract

Maintaining energy balance in fasting A fasting-inducible switch, consisting of the histone acetyl transferase p300 and the nutrient-sensing NAD+-dependent deacetylase SIRT1, is shown to maintain energy balance during fasting by promoting the sequential induction of the transcription factors TORC2 and FOXO1. This illustrates how the exchange of two gluconeogenic regulators during fasting maintains energy balance.

Suggested Citation

  • Yi Liu & Renaud Dentin & Danica Chen & Susan Hedrick & Kim Ravnskjaer & Simon Schenk & Jill Milne & David J. Meyers & Phil Cole & John Yates III & Jerrold Olefsky & Leonard Guarente & Marc Montminy, 2008. "A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange," Nature, Nature, vol. 456(7219), pages 269-273, November.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7219:d:10.1038_nature07349
    DOI: 10.1038/nature07349
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    Cited by:

    1. Zhenmei Yao & Ning Xu & Guoguo Shang & Haixing Wang & Hui Tao & Yunzhi Wang & Zhaoyu Qin & Subei Tan & Jinwen Feng & Jiajun Zhu & Fahan Ma & Sha Tian & Qiao Zhang & Yuanyuan Qu & Jun Hou & Jianming Gu, 2023. "Proteogenomics of different urothelial bladder cancer stages reveals distinct molecular features for papillary cancer and carcinoma in situ," Nature Communications, Nature, vol. 14(1), pages 1-25, December.
    2. Cecilia Pessoa Rodrigues & Aindrila Chatterjee & Meike Wiese & Thomas Stehle & Witold Szymanski & Maria Shvedunova & Asifa Akhtar, 2021. "Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice," Nature Communications, Nature, vol. 12(1), pages 1-21, December.

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