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Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications

Author

Listed:
  • Lauren G. Holden

    (Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA)

  • Courtney Prochnow

    (Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA)

  • Y. Paul Chang

    (Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA)

  • Ronda Bransteitter

    (Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA)

  • Linda Chelico

    (Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA)

  • Udayaditya Sen

    (Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA)

  • Raymond C. Stevens

    (The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA)

  • Myron F. Goodman

    (Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA)

  • Xiaojiang S. Chen

    (Molecular and Computational Biology, University of Southern California, Los Angeles, California 90089, USA)

Abstract

APOBEC proteins: deaminase domain structure This paper describes a high-resolution crystal structure of the catalytic deaminase CD2 domain of APOBEC3G, a human antiviral defence protein that restricts replication of HIV and hepatitis B virus. This structure will provide a basis to pursue further functional studies of proteins of the APOBEC superfamily that will facilitate our understanding of their important biological functions, such as how they interact with nucleic acid substrates for deamination, how their activity is regulated, and how they restrict HIV and other viral pathogens.

Suggested Citation

  • Lauren G. Holden & Courtney Prochnow & Y. Paul Chang & Ronda Bransteitter & Linda Chelico & Udayaditya Sen & Raymond C. Stevens & Myron F. Goodman & Xiaojiang S. Chen, 2008. "Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications," Nature, Nature, vol. 456(7218), pages 121-124, November.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7218:d:10.1038_nature07357
    DOI: 10.1038/nature07357
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    Cited by:

    1. Hanjing Yang & Josue Pacheco & Kyumin Kim & Ayub Bokani & Fumiaki Ito & Diako Ebrahimi & Xiaojiang S. Chen, 2024. "Molecular mechanism for regulating APOBEC3G DNA editing function by the non-catalytic domain," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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