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Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks

Author

Listed:
  • Daniel Zilberman

    (University of California, 211 Koshland Hall, Berkeley, California 94720, USA)

  • Devin Coleman-Derr

    (University of California, 211 Koshland Hall, Berkeley, California 94720, USA)

  • Tracy Ballinger

    (Fred Hutchinson Cancer Research Center, and,
    Howard Hughes Medical Institute, 1100 Fairview Avenue North, Seattle, Washington 98109, USA)

  • Steven Henikoff

    (Fred Hutchinson Cancer Research Center, and,
    Howard Hughes Medical Institute, 1100 Fairview Avenue North, Seattle, Washington 98109, USA)

Abstract

Plant chromatin: DNA methylation versus histone H2A.Z Although DNA methylation has been actively studied for several decades, the mechanism by which it causes gene silencing remains largely unknown. In contrast to DNA methylation, the histone variant H2A.Z promotes transcriptional competence in plants, animals and fungi. This paper reports the finding that regions of DNA methylation in the Arabidopsis thaliana genome are deficient in H2A.Z. DNA methylation appears to repress transcription by exclusion of H2A.Z. This suggets a novel relationship between a covalent modification of DNA and a core nucleosome component with an important role in organizing eukaryotic chromatin.

Suggested Citation

  • Daniel Zilberman & Devin Coleman-Derr & Tracy Ballinger & Steven Henikoff, 2008. "Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks," Nature, Nature, vol. 456(7218), pages 125-129, November.
    • Handle: RePEc:nat:nature:v:456:y:2008:i:7218:d:10.1038_nature07324
    DOI: 10.1038/nature07324
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    Cited by:

    1. Min Kyung Lee & Nasim Azizgolshani & Ze Zhang & Laurent Perreard & Fred W. Kolling & Lananh N. Nguyen & George J. Zanazzi & Lucas A. Salas & Brock C. Christensen, 2024. "Associations in cell type-specific hydroxymethylation and transcriptional alterations of pediatric central nervous system tumors," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Chirag Nepal & Jesper B. Andersen, 2023. "Alternative promoters in CpG depleted regions are prevalently associated with epigenetic misregulation of liver cancer transcriptomes," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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