IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v455y2008i7217d10.1038_nature07298.html
   My bibliography  Save this article

Concurrent nucleation of 16S folding and induced fit in 30S ribosome assembly

Author

Listed:
  • Tadepalli Adilakshmi

    (Present address: Weis Center for Research, Geisinger Medical Center, 100 North Academy Avenue, Danville, Pennsylvania 17822, USA (T.A.); Department of Molecular Genetics and Cell Biology, The University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA (D.L.B).)

  • Deepti L. Bellur

    (Present address: Weis Center for Research, Geisinger Medical Center, 100 North Academy Avenue, Danville, Pennsylvania 17822, USA (T.A.); Department of Molecular Genetics and Cell Biology, The University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA (D.L.B).)

  • Sarah A. Woodson

    (and)

Abstract

Induced fit in ribosome assembly Ribosome assembly has to be fast and efficient, given the demand for protein synthesis in rapidly dividing cells. In this work, Woodson and colleagues use a footprinting method with high time resolution to map how the structure of the small subunit's 16S rRNA changes as proteins assemble on it. While several regions of the rRNA adopt secondary structure rapidly, both the region of the decoding site and interactions between the 5′, central and 3′ regions require much more time to form, suggesting that an induced fit reaction is occurring.

Suggested Citation

  • Tadepalli Adilakshmi & Deepti L. Bellur & Sarah A. Woodson, 2008. "Concurrent nucleation of 16S folding and induced fit in 30S ribosome assembly," Nature, Nature, vol. 455(7217), pages 1268-1272, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7217:d:10.1038_nature07298
    DOI: 10.1038/nature07298
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07298
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07298?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yuishin Kosaka & Yumi Miyawaki & Megumi Mori & Shunsuke Aburaya & Chisato Nishizawa & Takeshi Chujo & Tatsuya Niwa & Takumi Miyazaki & Takashi Sugita & Mao Fukuyama & Hideki Taguchi & Kazuhito Tomizaw, 2025. "Autonomous ribosome biogenesis in vitro," Nature Communications, Nature, vol. 16(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:455:y:2008:i:7217:d:10.1038_nature07298. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.