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p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

Author

Listed:
  • Hongwu Zheng

    (Department of Medical Oncology,)

  • Haoqiang Ying

    (Department of Medical Oncology,)

  • Haiyan Yan

    (Department of Medical Oncology,)

  • Alec C. Kimmelman

    (Department of Medical Oncology,
    Harvard Radiation Oncology Program,)

  • David J. Hiller

    (Stanford University, Stanford, California 94305, USA)

  • An-Jou Chen

    (Department of Medical Oncology,)

  • Samuel R. Perry

    (Department of Medical Oncology,
    Center for Applied Cancer Science, Belfer Foundation Institute for Innovative Cancer Science,)

  • Giovanni Tonon

    (Department of Medical Oncology,)

  • Gerald C. Chu

    (Department of Medical Oncology,
    Center for Applied Cancer Science, Belfer Foundation Institute for Innovative Cancer Science,
    Department of Pathology,)

  • Zhihu Ding

    (Department of Medical Oncology,)

  • Jayne M. Stommel

    (Department of Medical Oncology,)

  • Katherine L. Dunn

    (Department of Medical Oncology,)

  • Ruprecht Wiedemeyer

    (Department of Medical Oncology,)

  • Mingjian J. You

    (Department of Medical Oncology,)

  • Cameron Brennan

    (Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA
    Weill-Cornell Medical College, New York, New York 10065, USA)

  • Y. Alan Wang

    (Department of Medical Oncology,
    Center for Applied Cancer Science, Belfer Foundation Institute for Innovative Cancer Science,)

  • Keith L. Ligon

    (Department of Medical Oncology,
    Center for Molecular Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Department of Pathology,
    Division of Neuropathology,)

  • Wing H. Wong

    (Stanford University, Stanford, California 94305, USA)

  • Lynda Chin

    (Department of Medical Oncology,
    Center for Applied Cancer Science, Belfer Foundation Institute for Innovative Cancer Science,
    Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Ronald A. DePinho

    (Department of Medical Oncology,
    Center for Applied Cancer Science, Belfer Foundation Institute for Innovative Cancer Science,
    Harvard Medical School, Boston, Massachusetts 02115, USA)

Abstract

Glioblastoma: large-scale genomics and a lab model The Cancer Genome Atlas, a large-scale genomics project to catalogue cancer-linked mutations, is starting to produce results. Glioblastoma, the most common brain cancer, was the first target for the project and the initial results, published AOP on 4 September, are now in print. Genes newly implicated in glioblastoma include tumour suppressors (NF1, RB1, ATM and APC) and several tyrosine kinase genes. Glioblastoma is extremely resistant to therapy, hence the potential importance of the development of a possible model system. Zheng et al. report that mice lacking the tumour suppressors p53 and Pten develop tumours resembling human glioblastomas, associated with increased Myc protein levels. As well as offering a potential system for testing therapeutics, this points to c-Myc as a possible drug target.

Suggested Citation

  • Hongwu Zheng & Haoqiang Ying & Haiyan Yan & Alec C. Kimmelman & David J. Hiller & An-Jou Chen & Samuel R. Perry & Giovanni Tonon & Gerald C. Chu & Zhihu Ding & Jayne M. Stommel & Katherine L. Dunn & R, 2008. "p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation," Nature, Nature, vol. 455(7216), pages 1129-1133, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7216:d:10.1038_nature07443
    DOI: 10.1038/nature07443
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    Cited by:

    1. Jian Zhong & Xujia Wu & Yixin Gao & Junju Chen & Maolei Zhang & Huangkai Zhou & Jia Yang & Feizhe Xiao & Xuesong Yang & Nunu Huang & Haoyue Qi & Xiuxing Wang & Fan Bai & Yu Shi & Nu Zhang, 2023. "Circular RNA encoded MET variant promotes glioblastoma tumorigenesis," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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