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MicroRNA-10b and breast cancer metastasis

Author

Listed:
  • Harriet E. Gee

    (Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital)

  • Carme Camps

    (Genomics Group, Wellcome Trust Centre for Human Genetics, The Henry Wellcome Building for Genomic Medicine, University of Oxford)

  • Francesca M. Buffa

    (Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital)

  • Stefano Colella

    (Genomics Group, Wellcome Trust Centre for Human Genetics, The Henry Wellcome Building for Genomic Medicine, University of Oxford)

  • Helen Sheldon

    (Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital)

  • Jonathan M. Gleadle

    (Flinders Medical Centre, Bedford Park, South Australia, 5042, Australia)

  • Jiannis Ragoussis

    (Genomics Group, Wellcome Trust Centre for Human Genetics, The Henry Wellcome Building for Genomic Medicine, University of Oxford)

  • Adrian L. Harris

    (Cancer Research UK Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital)

Abstract

Arising from: L. Ma, J. Teruya-Feldstein & R. A. Weinberg Nature 449, 682–688 (2007)10.1038/nature06174 ; Ma et al. reply MicroRNAs regulate messenger RNA expression but are frequently dysregulated in tumours. Ma et al.1 report that overexpression of microRNA-10b (miR-10b) initiates invasion and metastasis in models of breast cancer and that its expression in primary breast carcinomas correlates with clinical progression. We tested this in patients with primary breast cancer, of whom 92 had nodal metastases at diagnosis and 127 were node-negative. We found no significant association between miR-10b levels and metastasis or prognosis. Although we concede that miR-10b may have a biological effect in a few cells at the growing edge of a tumour, we believe that it is unlikely to correlate in whole tumour samples with clinical progression.

Suggested Citation

  • Harriet E. Gee & Carme Camps & Francesca M. Buffa & Stefano Colella & Helen Sheldon & Jonathan M. Gleadle & Jiannis Ragoussis & Adrian L. Harris, 2008. "MicroRNA-10b and breast cancer metastasis," Nature, Nature, vol. 455(7216), pages 8-9, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7216:d:10.1038_nature07362
    DOI: 10.1038/nature07362
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    Cited by:

    1. Hongbo Shi & Guangde Zhang & Meng Zhou & Liang Cheng & Haixiu Yang & Jing Wang & Jie Sun & Zhenzhen Wang, 2016. "Integration of Multiple Genomic and Phenotype Data to Infer Novel miRNA-Disease Associations," PLOS ONE, Public Library of Science, vol. 11(2), pages 1-15, February.

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