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Protein-folding location can regulate manganese-binding versus copper- or zinc-binding

Author

Listed:
  • Steve Tottey

    (Cell and Molecular Biosciences, Medical School, Newcastle University)

  • Kevin J. Waldron

    (Cell and Molecular Biosciences, Medical School, Newcastle University)

  • Susan J. Firbank

    (Cell and Molecular Biosciences, Medical School, Newcastle University)

  • Brian Reale

    (Cell and Molecular Biosciences, Medical School, Newcastle University)

  • Conrad Bessant

    (Cranfield Bioinformatics Group, Cranfield University, Bedfordshire, MK43 0AL, UK)

  • Katsuko Sato

    (Cell and Molecular Biosciences, Medical School, Newcastle University)

  • Timothy R. Cheek

    (Cell and Molecular Biosciences, Medical School, Newcastle University)

  • Joe Gray

    (Cell and Molecular Biosciences, Medical School, Newcastle University)

  • Mark J. Banfield

    (Cell and Molecular Biosciences, Medical School, Newcastle University)

  • Christopher Dennison

    (Cell and Molecular Biosciences, Medical School, Newcastle University)

  • Nigel J. Robinson

    (Cell and Molecular Biosciences, Medical School, Newcastle University)

Abstract

Protein folding: choosing the right metal Metal ions are needed by at least a quarter of proteins — although metallochaperones insert the 'correct' metal ion into some metal-containing proteins, metallochaperones have not been found for a large proportion of metalloproteins. It seems likely that some metalloproteins acquire their metal ions directly from cellular pools — but some metal ions form more stable metal ion/protein-complexes than others, so it is not clear what cellular mechanisms enables a nascent protein to incorporate the correct metal ion. In this manuscript, the authors identified the most abundant Cu2+ and Mn2+ containing proteins in the periplasm of a cyanobacterium and determined that the cellular compartment in which each of those proteins fold is responsible for the insertion of the correct metal ion into the metalloprotein.

Suggested Citation

  • Steve Tottey & Kevin J. Waldron & Susan J. Firbank & Brian Reale & Conrad Bessant & Katsuko Sato & Timothy R. Cheek & Joe Gray & Mark J. Banfield & Christopher Dennison & Nigel J. Robinson, 2008. "Protein-folding location can regulate manganese-binding versus copper- or zinc-binding," Nature, Nature, vol. 455(7216), pages 1138-1142, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7216:d:10.1038_nature07340
    DOI: 10.1038/nature07340
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    Cited by:

    1. Bixi He & Ankita J. Sachla & John D. Helmann, 2023. "TerC proteins function during protein secretion to metalate exoenzymes," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Sophie E. Clough & Tessa R. Young & Emma Tarrant & Andrew J. P. Scott & Peter T. Chivers & Arthur Glasfeld & Nigel J. Robinson, 2025. "A metal-trap tests and refines blueprints to engineer cellular protein metalation with different elements," Nature Communications, Nature, vol. 16(1), pages 1-15, December.

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