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Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells

Author

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  • Guonan Lin

    (Graduate program, Peking Union Medical College and Chinese Academy of Medical Sciences
    National Institute of Biological Sciences, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China)

  • Na Xu

    (National Institute of Biological Sciences, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China)

  • Rongwen Xi

    (National Institute of Biological Sciences, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing 102206, China)

Abstract

Intestinal stem cells Multipotent intestine stem cells (ISCs) are present in the Drosophila midgut, and Notch pathway activity promotes downstream lineage differentiation to produce either enterocytes or enteroendocrine cells. How homeostasis of this process is regulated is unknown. Now Guonan Lin, Na Xu and Rongwen Xi show that the canonical Wnt signalling pathway controls ISC self-renewal. They also show that Notch acts downstream of the Wnt pathway and a hierarchy of Wg-Notch signalling pathway controls the balance between self-renewal and differentiation of ISCs. Interestingly, the mechanisms regulating ISCs from Drosophila to mammals appear to be conserved.

Suggested Citation

  • Guonan Lin & Na Xu & Rongwen Xi, 2008. "Paracrine Wingless signalling controls self-renewal of Drosophila intestinal stem cells," Nature, Nature, vol. 455(7216), pages 1119-1123, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7216:d:10.1038_nature07329
    DOI: 10.1038/nature07329
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    Cited by:

    1. Xingting Guo & Chenhui Wang & Yongchao Zhang & Ruxue Wei & Rongwen Xi, 2024. "Cell-fate conversion of intestinal cells in adult Drosophila midgut by depleting a single transcription factor," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Xingting Guo & Yongchao Zhang & Huanwei Huang & Rongwen Xi, 2022. "A hierarchical transcription factor cascade regulates enteroendocrine cell diversity and plasticity in Drosophila," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    3. Zachary T. Spencer & Victoria H. Ng & Hassina Benchabane & Ghalia Saad Siddiqui & Deepesh Duwadi & Ben Maines & Jamal M. Bryant & Anna Schwarzkopf & Kai Yuan & Sara N. Kassel & Anant Mishra & Ashley P, 2023. "The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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