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Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis

Author

Listed:
  • Olivier Disson

    (Institut Pasteur, Groupe Microorganismes et Barrières de l’Hôte, Unité des Interactions Bactéries-Cellules
    Inserm Avenir U604)

  • Solène Grayo

    (Institut Pasteur, Groupe Microorganismes et Barrières de l’Hôte, Unité des Interactions Bactéries-Cellules
    Inserm Avenir U604
    Institut Pasteur, Centre National de Référence des Listeria)

  • Eugénie Huillet

    (Institut Pasteur, Unité des Interactions Bactéries-Cellules
    Inserm U604
    INRA USC2020)

  • Georgios Nikitas

    (Institut Pasteur, Groupe Microorganismes et Barrières de l’Hôte, Unité des Interactions Bactéries-Cellules
    Inserm Avenir U604)

  • Francina Langa-Vives

    (Institut Pasteur, Centre d’Ingénierie Génétique Murine)

  • Olivier Dussurget

    (Institut Pasteur, Unité des Interactions Bactéries-Cellules
    Inserm U604
    INRA USC2020)

  • Marie Ragon

    (Institut Pasteur, Centre National de Référence des Listeria)

  • Alban Le Monnier

    (Institut Pasteur, Centre National de Référence des Listeria)

  • Charles Babinet

    (Institut Pasteur, Unité de Biologie du Développement)

  • Pascale Cossart

    (Institut Pasteur, Unité des Interactions Bactéries-Cellules
    Inserm U604
    INRA USC2020)

  • Marc Lecuit

    (Institut Pasteur, Groupe Microorganismes et Barrières de l’Hôte, Unité des Interactions Bactéries-Cellules
    Inserm Avenir U604
    Institut Pasteur, Centre National de Référence des Listeria
    Centre d’Infectiologie Necker-Pasteur, Service des Maladies Infectieuses et Tropicales, Hôpital Necker-Enfants malades, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes)

Abstract

Crossing the placental barrier Listeriosis and other microbial infections in pregnancy can affect the fetus as well as the mother, but little is known about how pathogens cross the placental barrier. Disson et al. investigated the process using two complementary animal models infected by Listeria monocytogenes. They show that two virulence factors or invasion proteins, InlA and InlB, are required for the transfer of pathogen to the placenta. Thus by blocking one or both of these pathways it may be possible to stop microbes passing into the fetus. Conversely, it may be possible to exploit these pathways to target therapeutic molecules across the same barrier.

Suggested Citation

  • Olivier Disson & Solène Grayo & Eugénie Huillet & Georgios Nikitas & Francina Langa-Vives & Olivier Dussurget & Marie Ragon & Alban Le Monnier & Charles Babinet & Pascale Cossart & Marc Lecuit, 2008. "Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis," Nature, Nature, vol. 455(7216), pages 1114-1118, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7216:d:10.1038_nature07303
    DOI: 10.1038/nature07303
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    Cited by:

    1. Ana Teresa López-Jiménez & Serge Mostowy, 2021. "Emerging technologies and infection models in cellular microbiology," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    2. Maliha Sarfraz & Yasmin Ashraf & Samina Ashraf, 2017. "A Review: Prevalence and antimicrobial susceptibility profile of listeria species in milk products," Matrix Science Medica (MSM), Zibeline International Publishing, vol. 1(1), pages 3-9, February.

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