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MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation

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  • Yvonne Tay

    (Stem Cell and Developmental Biology, Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), #08-01, Genome, 60 Biopolis Street, Singapore 138672, Singapore
    Present address: Experimental Therapeutics Center, Agency for Science Technology and Research (A*STAR), Nanos Level 3, 31 Biopolis Way, Singapore 138669, Singapore.)

  • Jinqiu Zhang

    (Stem Cell and Developmental Biology, Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), #08-01, Genome, 60 Biopolis Street, Singapore 138672, Singapore)

  • Andrew M. Thomson

    (Stem Cell and Developmental Biology, Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), #08-01, Genome, 60 Biopolis Street, Singapore 138672, Singapore)

  • Bing Lim

    (Stem Cell and Developmental Biology, Genome Institute of Singapore, Agency for Science Technology and Research (A*STAR), #08-01, Genome, 60 Biopolis Street, Singapore 138672, Singapore
    Beth-Israel Medical Center, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02215, USA)

  • Isidore Rigoutsos

    (Bioinformatics and Pattern Discovery Group, IBM Thomas J. Watson Research Center, Yorktown Heights, PO Box 218, New York 10598, USA)

Abstract

Molecular biology: in the midst of things Most miRNA target sequences that have been studied reside in the 3′ UTR, the part of the messenger RNA that is downstream of the coding region. In this work Rigoutsos and colleagues demonstrate that the coding regions of several genes encoding transcription factors involved in the maintenance of stem cell identity, such as Nanog, Oct4, and Sox2, have miRNA target sites. Three miRNAs that are upregulated when embryonic stem cells are induced to differentiate bind these sites in various combinations, and thereby confer specific phenotypes.

Suggested Citation

  • Yvonne Tay & Jinqiu Zhang & Andrew M. Thomson & Bing Lim & Isidore Rigoutsos, 2008. "MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation," Nature, Nature, vol. 455(7216), pages 1124-1128, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7216:d:10.1038_nature07299
    DOI: 10.1038/nature07299
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    Cited by:

    1. Qing Li & Jiansen Lu & Xidi Yin & Yunjian Chang & Chao Wang & Meng Yan & Li Feng & Yanbo Cheng & Yun Gao & Beiying Xu & Yao Zhang & Yingyi Wang & Guizhong Cui & Luang Xu & Yidi Sun & Rong Zeng & Yixue, 2023. "Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Joan Teichenne & Meritxell Morró & Alba Casellas & Veronica Jimenez & Noelia Tellez & Adrien Leger & Fatima Bosch & Eduard Ayuso, 2015. "Identification of miRNAs Involved in Reprogramming Acinar Cells into Insulin Producing Cells," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-20, December.

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