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Copy-number variations associated with neuropsychiatric conditions

Author

Listed:
  • Edwin H. Cook Jr

    (Institute for Juvenile Research, University of Illinois, 1747 West Roosevelt Road, Chicago, Illinois 60608, USA.)

  • Stephen W. Scherer

    (The Centre for Applied Genomics, Hospital for Sick Children, 14th floor, Toronto Medical Discovery Tower/MaRS Discovery District
    University of Toronto, Room 4396, 1 King's Circle)

Abstract

Neuropsychiatric conditions such as autism and schizophrenia have long been attributed to genetic alterations, but identifying the genes responsible has proved challenging. Microarray experiments have now revealed abundant copy-number variation — a type of variation in which stretches of DNA are duplicated, deleted and sometimes rearranged — in the human population. Genes affected by copy-number variation are good candidates for research into disease susceptibility. The complexity of neuropsychiatric genetics, however, dictates that assessment of the biomedical relevance of copy-number variants and the genes that they affect needs to be considered in an integrated context.

Suggested Citation

  • Edwin H. Cook Jr & Stephen W. Scherer, 2008. "Copy-number variations associated with neuropsychiatric conditions," Nature, Nature, vol. 455(7215), pages 919-923, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7215:d:10.1038_nature07458
    DOI: 10.1038/nature07458
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    Cited by:

    1. Tetsushi Sadakata & Yo Shinoda & Akira Sato & Hirotoshi Iguchi & Chiaki Ishii & Makoto Matsuo & Ryosuke Yamaga & Teiichi Furuichi, 2013. "Mouse Models of Mutations and Variations in Autism Spectrum Disorder-Associated Genes: Mice Expressing Caps2/Cadps2 Copy Number and Alternative Splicing Variants," IJERPH, MDPI, vol. 10(12), pages 1-19, November.
    2. John Wiedenhoeft & Eric Brugel & Alexander Schliep, 2016. "Fast Bayesian Inference of Copy Number Variants using Hidden Markov Models with Wavelet Compression," PLOS Computational Biology, Public Library of Science, vol. 12(5), pages 1-28, May.
    3. Shanker Swaminathan & Matthew J Huentelman & Jason J Corneveaux & Amanda J Myers & Kelley M Faber & Tatiana Foroud & Richard Mayeux & Li Shen & Sungeun Kim & Mari Turk & John Hardy & Eric M Reiman & A, 2012. "Analysis of Copy Number Variation in Alzheimer’s Disease in a Cohort of Clinically Characterized and Neuropathologically Verified Individuals," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-12, December.
    4. Idan Menashe & Pascal Grange & Eric C Larsen & Sharmila Banerjee-Basu & Partha P Mitra, 2013. "Co-expression Profiling of Autism Genes in the Mouse Brain," PLOS Computational Biology, Public Library of Science, vol. 9(7), pages 1-10, July.

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