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Failure of neuronal homeostasis results in common neuropsychiatric phenotypes

Author

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  • Melissa B. Ramocki

    (Section of Pediatric Neurology and Developmental Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, MS 225, BCMT-T807)

  • Huda Y. Zoghbi

    (Section of Pediatric Neurology and Developmental Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, MS 225, BCMT-T807
    Section of Human and Molecular Genetics, Baylor College of Medicine, 1 Baylor Plaza, MS 225, BCMT-T807)

Abstract

Failure of normal brain development leads to mental retardation or autism in about 3% of children. Many genes integral to pathways by which synaptic modification and the remodelling of neuronal networks mediate cognitive and social development have been identified, usually through loss of function. Evidence is accumulating, however, that either loss or gain of molecular functions can be deleterious to the nervous system. Copy-number variation, regulation of gene expression by non-coding RNAs and epigenetic changes are all mechanisms by which altered gene dosage can cause the failure of neuronal homeostasis.

Suggested Citation

  • Melissa B. Ramocki & Huda Y. Zoghbi, 2008. "Failure of neuronal homeostasis results in common neuropsychiatric phenotypes," Nature, Nature, vol. 455(7215), pages 912-918, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7215:d:10.1038_nature07457
    DOI: 10.1038/nature07457
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    Cited by:

    1. Sarah Perry & Yifu Han & Chengjie Qiu & Chun Chien & Pragya Goel & Samantha Nishimura & Manisha Sajnani & Andreas Schmid & Stephan J. Sigrist & Dion Dickman, 2022. "A glutamate receptor C-tail recruits CaMKII to suppress retrograde homeostatic signaling," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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