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Neuroligins and neurexins link synaptic function to cognitive disease

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  • Thomas C. Südhof

    (Neuroscience Institute, and Howard Hughes Medical Institute, Stanford University)

Abstract

The brain processes information by transmitting signals at synapses, which connect neurons into vast networks of communicating cells. In these networks, synapses not only transmit signals but also transform and refine them. Neurexins and neuroligins are synaptic cell-adhesion molecules that connect presynaptic and postsynaptic neurons at synapses, mediate signalling across the synapse, and shape the properties of neural networks by specifying synaptic functions. In humans, alterations in genes encoding neurexins or neuroligins have recently been implicated in autism and other cognitive diseases, linking synaptic cell adhesion to cognition and its disorders.

Suggested Citation

  • Thomas C. Südhof, 2008. "Neuroligins and neurexins link synaptic function to cognitive disease," Nature, Nature, vol. 455(7215), pages 903-911, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7215:d:10.1038_nature07456
    DOI: 10.1038/nature07456
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    Cited by:

    1. Rosario Vicidomini & Saumitra Dey Choudhury & Tae Hee Han & Tho Huu Nguyen & Peter Nguyen & Felipe Opazo & Mihaela Serpe, 2024. "Versatile nanobody-based approach to image, track and reconstitute functional Neurexin-1 in vivo," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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