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Oncogenic mutations of ALK kinase in neuroblastoma

Author

Listed:
  • Yuyan Chen

    (Department of Pediatrics,
    Cell Therapy and Transplantation Medicine,
    Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan)

  • Junko Takita

    (Department of Pediatrics,
    Cell Therapy and Transplantation Medicine,
    Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan)

  • Young Lim Choi

    (Jichi Medical University)

  • Motohiro Kato

    (Department of Pediatrics,
    Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan)

  • Miki Ohira

    (Chiba Cancer Center Research Institute)

  • Masashi Sanada

    (Cell Therapy and Transplantation Medicine,
    Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency)

  • Lili Wang

    (Cell Therapy and Transplantation Medicine,
    Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency)

  • Manabu Soda

    (Jichi Medical University)

  • Akira Kikuchi

    (Saitama Children’s Medical Center)

  • Takashi Igarashi

    (Department of Pediatrics,)

  • Akira Nakagawara

    (Chiba Cancer Center Research Institute)

  • Yasuhide Hayashi

    (Gunma Children’s Medical Center)

  • Hiroyuki Mano

    (Jichi Medical University
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency)

  • Seishi Ogawa

    (Cell Therapy and Transplantation Medicine,
    Cancer Genomics Project, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan
    Core Research for Evolutional Science and Technology, Japan Science and Technology Agency)

Abstract

Neuroblastoma: a genetic link to ALK Neuroblastoma is the most common childhood cancer. There is a strong familial association and it was predicted over 30 years ago that there was a genetic element to the disease. Four groups now report the identification of mutations in the tyrosine kinase receptor ALK (anaplastic lymphoma kinase) in neuroblastoma patients. ALK acts as a neuroblastoma predisposition gene, and somatic point mutations occur in sporadic neuroblastoma cases. These mutations promote ALK's kinase activity and can transform cells and display tumorigenic activity in vivo. ALK inhibitors decrease neuroblastoma cell proliferation, so have potential as anticancer drugs.

Suggested Citation

  • Yuyan Chen & Junko Takita & Young Lim Choi & Motohiro Kato & Miki Ohira & Masashi Sanada & Lili Wang & Manabu Soda & Akira Kikuchi & Takashi Igarashi & Akira Nakagawara & Yasuhide Hayashi & Hiroyuki M, 2008. "Oncogenic mutations of ALK kinase in neuroblastoma," Nature, Nature, vol. 455(7215), pages 971-974, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7215:d:10.1038_nature07399
    DOI: 10.1038/nature07399
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    Cited by:

    1. Esther R. Berko & Gabriela M. Witek & Smita Matkar & Zaritza O. Petrova & Megan A. Wu & Courtney M. Smith & Alex Daniels & Joshua Kalna & Annie Kennedy & Ivan Gostuski & Colleen Casey & Kateryna Kryts, 2023. "Circulating tumor DNA reveals mechanisms of lorlatinib resistance in patients with relapsed/refractory ALK-driven neuroblastoma," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Cécile Thirant & Agathe Peltier & Simon Durand & Amira Kramdi & Caroline Louis-Brennetot & Cécile Pierre-Eugène & Margot Gautier & Ana Costa & Amandine Grelier & Sakina Zaïdi & Nadège Gruel & Irène Ji, 2023. "Reversible transitions between noradrenergic and mesenchymal tumor identities define cell plasticity in neuroblastoma," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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