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The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

Author

Listed:
  • Jason S. McLellan

    (Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • Xiaoyan Zheng

    (and)

  • Glenn Hauk

    (Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

  • Rodolfo Ghirlando

    (Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, Maryland 20892, USA)

  • Philip A. Beachy

    (and
    Howard Hughes Medical Institute Stanford University School of Medicine, Stanford, California 94305, USA)

  • Daniel J. Leahy

    (Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA)

Abstract

Hedgehog signalling: variations on the theme The Hedgehog signalling pathway specifies tissue pattern in metazoan embryos. Intriguingly, the crystal structure of the human Sonic Hedgehog protein Shh complexed with a fragment of the cell surface protein CDO (the vertebrate equivalent of Ihog in Drosophila) reveals that the mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. The interaction between human Shh and CDO involves a previously unrecognized calcium-binding site in Shh that is buried at the interface between the two proteins. Mutations in Shh causing congenital malformations map to the calcium-binding site and disrupt interactions with binding partners.

Suggested Citation

  • Jason S. McLellan & Xiaoyan Zheng & Glenn Hauk & Rodolfo Ghirlando & Philip A. Beachy & Daniel J. Leahy, 2008. "The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla," Nature, Nature, vol. 455(7215), pages 979-983, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7215:d:10.1038_nature07358
    DOI: 10.1038/nature07358
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    Cited by:

    1. Adrian On Wah Leung & Andrew Chung Hin Poon & Xue Wang & Chen Feng & Peikai Chen & Zhengfan Zheng & Michael KaiTsun To & Wilson Cheuk Wing Chan & Martin Cheung & Danny Chan, 2024. "Suppression of apoptosis impairs phalangeal joint formation in the pathogenesis of brachydactyly type A1," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    2. Wanqiu Li & Linlin Wang & Bradley M. Wierbowski & Mo Lu & Feitong Dong & Wenchen Liu & Sisi Li & Peiyi Wang & Adrian Salic & Xin Gong, 2021. "Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen release," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
    3. Samuel C. Griffiths & Rebekka A. Schwab & Kamel El Omari & Benjamin Bishop & Ellen J. Iverson & Tomas Malinauskas & Ramin Dubey & Mingxing Qian & Douglas F. Covey & Robert J. C. Gilbert & Rajat Rohatg, 2021. "Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling," Nature Communications, Nature, vol. 12(1), pages 1-13, December.

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