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Challenges in the development of an HIV-1 vaccine

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  • Dan H. Barouch

    (Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA)

Abstract

HIV/AIDS The long road to vaccines Two pieces in this issue focus on what must be one of the top priorities in science today: the quest for a viable HIV/AIDS vaccine. Dan Barouch's Review Article charts the trials and tribulations of work that has so far led only to failed vaccine candidates. Barouch argues that HIV-1 vaccine science is still in its infancy, and that a renewed emphasis on basic discovery research is needed if the field is to advance. Ruslan Medzhitov and Dan Littman also stress the need for basic research, principally in immunology, where some of the established models and assumptions may simply not be relevant to retroviral infections.

Suggested Citation

  • Dan H. Barouch, 2008. "Challenges in the development of an HIV-1 vaccine," Nature, Nature, vol. 455(7213), pages 613-619, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7213:d:10.1038_nature07352
    DOI: 10.1038/nature07352
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    Cited by:

    1. Ziyang Xu & Susanne Walker & Megan C. Wise & Neethu Chokkalingam & Mansi Purwar & Alan Moore & Edgar Tello-Ruiz & Yuanhan Wu & Sonali Majumdar & Kylie M. Konrath & Abhijeet Kulkarni & Nicholas J. Turs, 2022. "Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    2. Pius Babuna & Xiaohua Yang & Amatus Gyilbag & Doris Abra Awudi & David Ngmenbelle & Dehui Bian, 2020. "The Impact of COVID-19 on the Insurance Industry," IJERPH, MDPI, vol. 17(16), pages 1-14, August.

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