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Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation

Author

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  • Valentina Gandin

    (Molecular Histology and Cell Growth Laboratory, San Raffaele Science Institute, Via Olgettina 58, 20132 Milan, Italy)

  • Annarita Miluzio

    (Molecular Histology and Cell Growth Laboratory, San Raffaele Science Institute, Via Olgettina 58, 20132 Milan, Italy)

  • Anna Maria Barbieri

    (Molecular Histology and Cell Growth Laboratory, San Raffaele Science Institute, Via Olgettina 58, 20132 Milan, Italy)

  • Anne Beugnet

    (Molecular Histology and Cell Growth Laboratory, San Raffaele Science Institute, Via Olgettina 58, 20132 Milan, Italy)

  • Hiroaki Kiyokawa

    (Northwestern University, Feinberg School of Medicine, 303 East Avenue Chicago, Chicago, Illinois 60611, USA)

  • Pier Carlo Marchisio

    (Molecular Histology and Cell Growth Laboratory, San Raffaele Science Institute, Via Olgettina 58, 20132 Milan, Italy
    Università Vita-Salute, Medical School, Via Olgettina 58, 20132 Milan, Italy)

  • Stefano Biffo

    (Molecular Histology and Cell Growth Laboratory, San Raffaele Science Institute, Via Olgettina 58, 20132 Milan, Italy
    DISAV, University of Eastern Piedmont, Via Bellini 8G, 15100 Alessandria, Italy)

Abstract

eIF6: transmitter to the 60S ribosome Translation initiation is influenced by input from extracellular stimuli. While two eukaryotic initiation factors (eIFs) are known to transduce external signals to the small (40S) ribosomal subunit, it was not known whether an eIF served a similar function for the large (60S) ribosomal subunit. In this study, Gandin et al. show that eIF6 communicates extracellular signals to the 60S subunit. Cells from an eIF6 heterozygous mouse show normal ribosome assembly but reduced translation, delayed cell cycle progression, and impaired transformation. This work suggests that eIF6 acts an initiation factor, in vivo, and may control growth and tumorigenesis.

Suggested Citation

  • Valentina Gandin & Annarita Miluzio & Anna Maria Barbieri & Anne Beugnet & Hiroaki Kiyokawa & Pier Carlo Marchisio & Stefano Biffo, 2008. "Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation," Nature, Nature, vol. 455(7213), pages 684-688, October.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7213:d:10.1038_nature07267
    DOI: 10.1038/nature07267
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    Cited by:

    1. Pekka Jaako & Alexandre Faille & Shengjiang Tan & Chi C. Wong & Norberto Escudero-Urquijo & Pablo Castro-Hartmann & Penny Wright & Christine Hilcenko & David J. Adams & Alan J. Warren, 2022. "eIF6 rebinding dynamically couples ribosome maturation and translation," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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