IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v455y2008i7212d10.1038_nature07265.html
   My bibliography  Save this article

Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer

Author

Listed:
  • Samuel P. Gubbels

    (Oregon Hearing Research Center, and
    Present addresses: Department of Surgery, Division of Otolaryngology, University of Wisconsin – Madison, K4/719 CSC, 600 Highland Avenue, Madison, Wisconsin 53792, USA (S.P.G.); Department of Pharmacology and Toxicology, University of Utah, College of Pharmacy, 30 South 2000 East, Room 201, Salt Lake City, Utah 84112, USA (D.W.W.).)

  • David W. Woessner

    (Oregon Hearing Research Center, and
    Present addresses: Department of Surgery, Division of Otolaryngology, University of Wisconsin – Madison, K4/719 CSC, 600 Highland Avenue, Madison, Wisconsin 53792, USA (S.P.G.); Department of Pharmacology and Toxicology, University of Utah, College of Pharmacy, 30 South 2000 East, Room 201, Salt Lake City, Utah 84112, USA (D.W.W.).)

  • John C. Mitchell

    (School of Dentistry, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA)

  • Anthony J. Ricci

    (Stanford University School of Medicine, 801 Welch Road, Stanford, California 94305, USA)

  • John V. Brigande

    (Oregon Hearing Research Center, and)

Abstract

Hair-cell triggers Cochlear hair cells form the sound-sensing apparatus of vertebrates and their loss or damage results in hearing impairment. Mammals cannot regenerate these cells, but previous work has shown that ectopic expression of the transcription factor Atonal homologue 1 (Atoh1) can induce cells that would not normally differentiate as cochlear hair cells to become hair cell-like. Now Gubbels et al. show that in utero gene transfer of Atoh1 into mouse cochleas generates ectopic hair cells in the cochlea. Importantly, these supernumerary hair cells are functionally competent and display neuronal connectivity. This is a major step towards experiments to test for the ability of gene therapies to ameliorate hearing loss in mouse models of human deafness.

Suggested Citation

  • Samuel P. Gubbels & David W. Woessner & John C. Mitchell & Anthony J. Ricci & John V. Brigande, 2008. "Functional auditory hair cells produced in the mammalian cochlea by in utero gene transfer," Nature, Nature, vol. 455(7212), pages 537-541, September.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7212:d:10.1038_nature07265
    DOI: 10.1038/nature07265
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07265
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07265?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Tian Wang & Tian Yang & Amanda Kedaigle & Gabriela Pregernig & Ryan McCarthy & Ben Holmes & Xudong Wu & Lars Becker & Ning Pan & Kathy So & Leon Chen & Jun He & Ahmad Mahmoudi & Soumya Negi & Monika K, 2024. "Precise genetic control of ATOH1 enhances maturation of regenerated hair cells in the mature mouse utricle," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:455:y:2008:i:7212:d:10.1038_nature07265. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.