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FcRn-mediated antibody transport across epithelial cells revealed by electron tomography

Author

Listed:
  • Wanzhong He

    (Division of Biology 114-96 and,
    National University of Singapore, 14 Science Drive 4, Singapore 117543)

  • Mark S. Ladinsky

    (Boulder Laboratory for 3D Electron Microscopy of Cells, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA)

  • Kathryn E. Huey-Tubman

    (Division of Biology 114-96 and,
    Howard Hughes Medical Institute, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA)

  • Grant J. Jensen

    (Division of Biology 114-96 and,)

  • J. Richard McIntosh

    (Boulder Laboratory for 3D Electron Microscopy of Cells, Cellular and Developmental Biology, University of Colorado, Boulder, Colorado 80309, USA)

  • Pamela J. Björkman

    (Division of Biology 114-96 and,
    Howard Hughes Medical Institute, California Institute of Technology, 1200 East California Boulevard, Pasadena, California 91125, USA)

Abstract

Delivering maternal antibodies The Fc receptor of neonates (FcRn) mediates the apical-to-basolateral transcytosis of immunoglobulin G (IgG) across epithelial cells so that newborns are able to receive maternal antibodies. In this study Her et al. use electron tomography to visualize the transport of IgG during this process with a resolution of 4–6 nm. Individual FcRn ligands were identified inside intracellular organelles using a new gold enlargement technique compatible with high pressure frozen samples. The transcytosis pathways revealed show labelled-Fc moving through networks of vesicles as it migrates from the apical to basolateral surface.

Suggested Citation

  • Wanzhong He & Mark S. Ladinsky & Kathryn E. Huey-Tubman & Grant J. Jensen & J. Richard McIntosh & Pamela J. Björkman, 2008. "FcRn-mediated antibody transport across epithelial cells revealed by electron tomography," Nature, Nature, vol. 455(7212), pages 542-546, September.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7212:d:10.1038_nature07255
    DOI: 10.1038/nature07255
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    Cited by:

    1. Weizhong Li & Tao Wang & Arunraj M. Rajendrakumar & Gyanada Acharya & Zizhen Miao & Berin P. Varghese & Hailiang Yu & Bibek Dhakal & Tanya LeRoith & Athira Karunakaran & Wenbin Tuo & Xiaoping Zhu, 2023. "An FcRn-targeted mucosal vaccine against SARS-CoV-2 infection and transmission," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Jose-Ignacio Agulleiro & José Jesús Fernández, 2012. "Evaluation of a Multicore-Optimized Implementation for Tomographic Reconstruction," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-15, November.
    3. Maximilian Brinkhaus & Erwin Pannecoucke & Elvera J. Kooi & Arthur E. H. Bentlage & Ninotska I. L. Derksen & Julie Andries & Bianca Balbino & Magdalena Sips & Peter Ulrichts & Peter Verheesen & Hans H, 2022. "The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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