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Replication fork movement sets chromatin loop size and origin choice in mammalian cells

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  • Sylvain Courbet

    (Institut Curie, 26 rue d’Ulm, 75248 Paris, France
    UPMC Univ. Paris 06)

  • Sophie Gay

    (Institut Curie, 26 rue d’Ulm, 75248 Paris, France
    UPMC Univ. Paris 06)

  • Nausica Arnoult

    (Institut Curie, 26 rue d’Ulm, 75248 Paris, France
    UPMC Univ. Paris 06)

  • Gerd Wronka

    (Institut Curie, 26 rue d’Ulm, 75248 Paris, France
    UPMC Univ. Paris 06)

  • Mauro Anglana

    (Institut Curie, 26 rue d’Ulm, 75248 Paris, France
    UPMC Univ. Paris 06)

  • Olivier Brison

    (Institut Curie, 26 rue d’Ulm, 75248 Paris, France
    UPMC Univ. Paris 06)

  • Michelle Debatisse

    (Institut Curie, 26 rue d’Ulm, 75248 Paris, France
    UPMC Univ. Paris 06)

Abstract

Chromatin kept in the loop In mammalian cells, the genome undergoes one round of replication per cell cycle. Many origins of replication are never fired, but they serve as a reservoir to be activated if part of the genome is in danger of not being replicated — when progression of a replication fork stalls, for example. Courbet et al. show that latent origins can also be activated by slowing of replication fork progression, and this influences the size of the chromatin loop. In addition, they find that origins located nearby the attachment point of chromatin loops to the nuclear matrix are preferentially activated in the next cell cycle.

Suggested Citation

  • Sylvain Courbet & Sophie Gay & Nausica Arnoult & Gerd Wronka & Mauro Anglana & Olivier Brison & Michelle Debatisse, 2008. "Replication fork movement sets chromatin loop size and origin choice in mammalian cells," Nature, Nature, vol. 455(7212), pages 557-560, September.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7212:d:10.1038_nature07233
    DOI: 10.1038/nature07233
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    Cited by:

    1. Michel G Gauthier & Paolo Norio & John Bechhoefer, 2012. "Modeling Inhomogeneous DNA Replication Kinetics," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-13, March.

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