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Natural products as inspiration for the development of asymmetric catalysis

Author

Listed:
  • Justin T. Mohr

    (The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, California Institute of Technology, 1200 East California Boulevard, MC 164-30)

  • Michael R. Krout

    (The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, California Institute of Technology, 1200 East California Boulevard, MC 164-30)

  • Brian M. Stoltz

    (The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, California Institute of Technology, 1200 East California Boulevard, MC 164-30)

Abstract

Biologically active natural products often contain particularly challenging structural features and functionalities in terms of synthesis. Perhaps the greatest difficulties are those caused by issues of stereochemistry. A useful strategy for synthesizing such molecules is to devise methods of bond formation that provide opportunities for using enantioselective catalysis. In using this tactic, the desire for a particular target structure ultimately drives the development of catalytic methods. New enantioselective catalytic methods contribute to a greater fundamental understanding of how bonds can be constructed and lead to valuable synthetic technologies that are useful for a variety of applications.

Suggested Citation

  • Justin T. Mohr & Michael R. Krout & Brian M. Stoltz, 2008. "Natural products as inspiration for the development of asymmetric catalysis," Nature, Nature, vol. 455(7211), pages 323-332, September.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7211:d:10.1038_nature07370
    DOI: 10.1038/nature07370
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    Cited by:

    1. Zexian Li & Minyan Wang & Youqing Yang & Yong Liang & Xiangyang Chen & Yue Zhao & K. N. Houk & Zhuangzhi Shi, 2023. "Atroposelective hydroarylation of biaryl phosphines directed by phosphorus centres," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    2. Song-Meng Wang & Yan-Fang Wang & Liping Huang & Li-Shuo Zheng & Hao Nian & Yu-Tao Zheng & Huan Yao & Wei Jiang & Xiaoping Wang & Liu-Pan Yang, 2023. "Chiral recognition of neutral guests by chiral naphthotubes with a bis-thiourea endo-functionalized cavity," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

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