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A paracrine requirement for hedgehog signalling in cancer

Author

Listed:
  • Robert L. Yauch

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Stephen E. Gould

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Suzie J. Scales

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Tracy Tang

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Hua Tian

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Christina P. Ahn

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Derek Marshall

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Ling Fu

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Thomas Januario

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Dara Kallop

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Michelle Nannini-Pepe

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Karen Kotkow

    (Curis Inc., 45 Moulton Street, Cambridge, Massachusetts 02138, USA
    Present address: Harvard Stem Cell Institute, Harvard University, Biolabs Room 1065, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA.)

  • James C. Marsters

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

  • Lee L. Rubin

    (Curis Inc., 45 Moulton Street, Cambridge, Massachusetts 02138, USA
    Present address: Harvard Stem Cell Institute, Harvard University, Biolabs Room 1065, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA.)

  • Frederic J. de Sauvage

    (Genentech Inc., 1 DNA Way, South San Francisco, California 94080, USA)

Abstract

Hedgehog signalling in cancer The hedgehog (Hh) signalling pathway acts in the developing embryo as part of the network controlling cell proliferation and cell fate. It has also been implicated in a number of solid tumours, where it was thought to mediate tumour cell proliferation directly. But a new study suggests a rather different role for hedgehog in cancers. Hedgehog ligands secreted by cancer cells failed to activate signalling in tumour epithelial cells but instead acted on the stroma, the mass of extracellular matrix, fibroblasts, endothelial cells and microvasculature in which the malignant cells are embedded. Tumour growth was promoted, but apparently via an effect on the tumour cells' microenvironment. These findings have important implications for the use of hedgehog antagonists as anticancer drugs.

Suggested Citation

  • Robert L. Yauch & Stephen E. Gould & Suzie J. Scales & Tracy Tang & Hua Tian & Christina P. Ahn & Derek Marshall & Ling Fu & Thomas Januario & Dara Kallop & Michelle Nannini-Pepe & Karen Kotkow & Jame, 2008. "A paracrine requirement for hedgehog signalling in cancer," Nature, Nature, vol. 455(7211), pages 406-410, September.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7211:d:10.1038_nature07275
    DOI: 10.1038/nature07275
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    Cited by:

    1. Sebastien Martinez & Shifei Wu & Michael Geuenich & Ahmad Malik & Ramona Weber & Tristan Woo & Amy Zhang & Gun Ho Jang & Dzana Dervovic & Khalid N. Al-Zahrani & Ricky Tsai & Nassima Fodil & Philippe G, 2024. "In vivo CRISPR screens reveal SCAF1 and USP15 as drivers of pancreatic cancer," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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