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S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons

Author

Listed:
  • Alexi Nott

    (MRC Laboratory for Molecular and Cell Biology, Physiology and Pharmacology, University College London)

  • P. Marc Watson

    (MRC Laboratory for Molecular and Cell Biology, Physiology and Pharmacology, University College London)

  • James D. Robinson

    (MRC Laboratory for Molecular and Cell Biology, Physiology and Pharmacology, University College London)

  • Luca Crepaldi

    (MRC Laboratory for Molecular and Cell Biology, Physiology and Pharmacology, University College London)

  • Antonella Riccio

    (MRC Laboratory for Molecular and Cell Biology, Physiology and Pharmacology, University College London)

Abstract

Development: the BDNF trigger The neurotrophin BDNF (brain-derived neurotrophic factor) influences the expression of many genes in the developing nervous system and is known to induce nitric oxide. Nott et al. show that BDNF triggers nitric oxide synthesis and accompanying S-nitrosylation of several proteins in the nucleus of cortical neurons, including the histone deacetylase HDAC2. Nitrosylation of HDAC2 leads to its release from the chromatin of neurotrophin-dependent genes, which allows histone acetylation and active transcription.

Suggested Citation

  • Alexi Nott & P. Marc Watson & James D. Robinson & Luca Crepaldi & Antonella Riccio, 2008. "S-nitrosylation of histone deacetylase 2 induces chromatin remodelling in neurons," Nature, Nature, vol. 455(7211), pages 411-415, September.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7211:d:10.1038_nature07238
    DOI: 10.1038/nature07238
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    Cited by:

    1. Yan Xu & Jun Ding & Ling-Yun Wu & Kuo-Chen Chou, 2013. "iSNO-PseAAC: Predict Cysteine S-Nitrosylation Sites in Proteins by Incorporating Position Specific Amino Acid Propensity into Pseudo Amino Acid Composition," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-7, February.
    2. Kosaku Okuda & Kengo Nakahara & Akihiro Ito & Yuta Iijima & Ryosuke Nomura & Ashutosh Kumar & Kana Fujikawa & Kazuya Adachi & Yuki Shimada & Satoshi Fujio & Reina Yamamoto & Nobumasa Takasugi & Kunish, 2023. "Pivotal role for S-nitrosylation of DNA methyltransferase 3B in epigenetic regulation of tumorigenesis," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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