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Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

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  • Jelena Nedjic

    (Research Institute of Molecular Pathology, Doktor Bohr Gasse 7, 1030 Vienna, Austria
    Present addresses: Institute for Immunology, Ludwig-Maximilians-University, Goethestrasse 31, 80336 Munich, Germany (J.N., M.A.); Schering-Plough BioPharma (formerly DNAX, Inc.), 901 California Avenue, Palo Alto, California 94304, USA (J.E.).)

  • Martin Aichinger

    (Research Institute of Molecular Pathology, Doktor Bohr Gasse 7, 1030 Vienna, Austria
    Present addresses: Institute for Immunology, Ludwig-Maximilians-University, Goethestrasse 31, 80336 Munich, Germany (J.N., M.A.); Schering-Plough BioPharma (formerly DNAX, Inc.), 901 California Avenue, Palo Alto, California 94304, USA (J.E.).)

  • Jan Emmerich

    (Research Institute of Molecular Pathology, Doktor Bohr Gasse 7, 1030 Vienna, Austria
    Present addresses: Institute for Immunology, Ludwig-Maximilians-University, Goethestrasse 31, 80336 Munich, Germany (J.N., M.A.); Schering-Plough BioPharma (formerly DNAX, Inc.), 901 California Avenue, Palo Alto, California 94304, USA (J.E.).)

  • Noboru Mizushima

    (Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8613, Japan)

  • Ludger Klein

    (Research Institute of Molecular Pathology, Doktor Bohr Gasse 7, 1030 Vienna, Austria
    Institute for Immunology, Ludwig-Maximilians-University, Goethestrasse 31, 80336 Munich, Germany)

Abstract

T-cell tolerance Macro-autophagy in thymic epithelial cells is shown to contribute to endogenous antigen processing and selection of major histocompatibility complex class II (MHC II)-restricted CD4 T cells. This suggests that autophagy focuses the MHC class II/peptide repertoire of these T cells on their intracellular milieu, which is made up of a wide array of otherwise strictly 'tissue-specific' self-antigens. In doing so, it contributes to efficient positive selection and is essential for the generation of a self-tolerant T-cell repertoire.

Suggested Citation

  • Jelena Nedjic & Martin Aichinger & Jan Emmerich & Noboru Mizushima & Ludger Klein, 2008. "Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance," Nature, Nature, vol. 455(7211), pages 396-400, September.
    • Handle: RePEc:nat:nature:v:455:y:2008:i:7211:d:10.1038_nature07208
    DOI: 10.1038/nature07208
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    Cited by:

    1. Yuki Takakura & Moeka Machida & Natsumi Terada & Yuka Katsumi & Seika Kawamura & Kenta Horie & Maki Miyauchi & Tatsuya Ishikawa & Nobuko Akiyama & Takao Seki & Takahisa Miyao & Mio Hayama & Rin Endo &, 2024. "Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity," Nature Communications, Nature, vol. 15(1), pages 1-19, December.

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