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New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

Author

Listed:
  • Yu-Hua Tseng

    (Section on Obesity and Hormone Action, and,)

  • Efi Kokkotou

    (Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, 02215, USA)

  • Tim J. Schulz

    (Section on Obesity and Hormone Action, and,)

  • Tian Lian Huang

    (Section on Obesity and Hormone Action, and,)

  • Jonathon N. Winnay

    (Section on Obesity and Hormone Action, and,)

  • Cullen M. Taniguchi

    (Section on Obesity and Hormone Action, and,)

  • Thien T. Tran

    (Section on Obesity and Hormone Action, and,)

  • Ryo Suzuki

    (Section on Obesity and Hormone Action, and,)

  • Daniel O. Espinoza

    (Section on Obesity and Hormone Action, and,)

  • Yuji Yamamoto

    (Section on Obesity and Hormone Action, and,)

  • Molly J. Ahrens

    (Northwestern University, Evanston, Illinois 60208, USA)

  • Andrew T. Dudley

    (Northwestern University, Evanston, Illinois 60208, USA)

  • Andrew W. Norris

    (University of Iowa Children’s Hospital, Iowa City, Iowa 52242, USA)

  • Rohit N. Kulkarni

    (Section on Cell and Molecular Physiology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, 02215, USA)

  • C. Ronald Kahn

    (Section on Obesity and Hormone Action, and,)

Abstract

BMP-7 and obesity Originally identified as a bone inducer, BMP-7 also has potent renal- and neuro-regenerative effects. Now it is reported to regulate energy homeostasis by promoting differentiation of brown, but not white, fat cells. BMP-7 switches on regulators of brown fat, including PRDM16 (see the cover story) and adipogenic transcription factors, and stimulates mitochondrial biogenesis. Ectopic expression of BMP-7 in mice increases brown, but not white, fat mass and leads to an increase in energy expenditure and reduced weight gain. These results have obvious therapeutic implications for the treatment of obesity.

Suggested Citation

  • Yu-Hua Tseng & Efi Kokkotou & Tim J. Schulz & Tian Lian Huang & Jonathon N. Winnay & Cullen M. Taniguchi & Thien T. Tran & Ryo Suzuki & Daniel O. Espinoza & Yuji Yamamoto & Molly J. Ahrens & Andrew T., 2008. "New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure," Nature, Nature, vol. 454(7207), pages 1000-1004, August.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7207:d:10.1038_nature07221
    DOI: 10.1038/nature07221
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    Cited by:

    1. Zan Li & Baohong Shi & Na Li & Jun Sun & Xiangchen Zeng & Rui Huang & Seoyeon Bok & Xiaohui Chen & Jie Han & Alisha R. Yallowitz & Shawon Debnath & Michelle Cung & Zheng Ling & Chuan-Qi Zhong & Yixang, 2024. "Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

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