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A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA

Author

Listed:
  • Monika Martick

    (Center for Molecular Biology of RNA, University of California, Santa Cruz, California 95064, USA)

  • Lucas H. Horan

    (Center for Molecular Biology of RNA, University of California, Santa Cruz, California 95064, USA)

  • Harry F. Noller

    (Center for Molecular Biology of RNA, University of California, Santa Cruz, California 95064, USA)

  • William G. Scott

    (Center for Molecular Biology of RNA, University of California, Santa Cruz, California 95064, USA)

Abstract

Hammerhead ribozyme and gene regulation An active ribozyme which can regulate gene expression was previously identified in bacteria, but whether there are similar regulatory ribozymes in eukaryotes was unknown. In this study, Martick et al. identify active ribozymes in the 3' UTRs of several rodent lectin genes. Unusually, these hammerhead ribozymes have a split structure, such that both halves must self-cleave and reassemble to give activity. Some data show that these ribozymes may potentially regulate gene expression, although further work will be necessary to confirm this function.

Suggested Citation

  • Monika Martick & Lucas H. Horan & Harry F. Noller & William G. Scott, 2008. "A discontinuous hammerhead ribozyme embedded in a mammalian messenger RNA," Nature, Nature, vol. 454(7206), pages 899-902, August.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7206:d:10.1038_nature07117
    DOI: 10.1038/nature07117
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    Cited by:

    1. Xuelin Zhan & Timothy J. Wilson & Zhenzhen Li & Jingjing Zhang & Yili Yang & David M. J. Lilley & Yijin Liu, 2024. "The structure and catalytic mechanism of a pseudoknot-containing hammerhead ribozyme," Nature Communications, Nature, vol. 15(1), pages 1-8, December.

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