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Minimally invasive high-speed imaging of sarcomere contractile dynamics in mice and humans

Author

Listed:
  • Michael E. Llewellyn

    (Bio-X Program, James H. Clark Center for Biomedical Engineering & Sciences, Stanford University, Stanford, California 94305, USA)

  • Robert P. J. Barretto

    (Bio-X Program, James H. Clark Center for Biomedical Engineering & Sciences, Stanford University, Stanford, California 94305, USA)

  • Scott L. Delp

    (Bio-X Program, James H. Clark Center for Biomedical Engineering & Sciences, Stanford University, Stanford, California 94305, USA)

  • Mark J. Schnitzer

    (Bio-X Program, James H. Clark Center for Biomedical Engineering & Sciences, Stanford University, Stanford, California 94305, USA)

Abstract

Muscle contraction: sarcomeres in close-up Sarcomeres are the basic contractile units of striated muscle. Uncovering how sarcomeres change length and develop force is fundamental to understanding biomechanics, muscle physiology, and neuromuscular control. Llewellyn et al. describe the use of optical microendoscopy to visualize sarcomeres and their micrometre-scale motions in live mice and humans, revealing unanticipated local variations in sarcomere lengths. Imaging of human sarcomeres is expected to enable advances in biomechanical modelling, orthopaedic therapeutics, and the understanding and treatment of neuromuscular disorders.

Suggested Citation

  • Michael E. Llewellyn & Robert P. J. Barretto & Scott L. Delp & Mark J. Schnitzer, 2008. "Minimally invasive high-speed imaging of sarcomere contractile dynamics in mice and humans," Nature, Nature, vol. 454(7205), pages 784-788, August.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7205:d:10.1038_nature07104
    DOI: 10.1038/nature07104
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    Cited by:

    1. Xinglei Liu & Lu Rao & Weihong Qiu & Florian Berger & Arne Gennerich, 2024. "Kinesin-14 HSET and KlpA are non-processive microtubule motors with load-dependent power strokes," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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