IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v454y2008i7205d10.1038_nature07103.html
   My bibliography  Save this article

MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs

Author

Listed:
  • Jennifer Lin Umbach

    (Duke University Medical Center, Durham, North Caroline 27710, USA)

  • Martha F. Kramer

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Igor Jurak

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Heather W. Karnowski

    (Duke University Medical Center, Durham, North Caroline 27710, USA)

  • Donald M. Coen

    (Harvard Medical School, Boston, Massachusetts 02115, USA)

  • Bryan R. Cullen

    (Duke University Medical Center, Durham, North Caroline 27710, USA)

Abstract

How miRNA hides cold sores The cold sore virus HSV-1 (herpes simplex virus 1) is notorious for its ability to lie dormant for months or years, allowing it to maintain life-long latent infections. The viral gene LAT, is known to be a key factor in inducing dormancy and now its non-coding RNA product has been identified as a precursor to four microRNAs (miRNAs), one of which appears to switch off viral gene expression in latently infected neurons. A second miRNA, not coded by LAT but with similar activity was also discovered. This raises the possibility that drugs based on blocking these miRNAs could in theory 'wake up, the virus, making them vulnerable to antiviral therapy.

Suggested Citation

  • Jennifer Lin Umbach & Martha F. Kramer & Igor Jurak & Heather W. Karnowski & Donald M. Coen & Bryan R. Cullen, 2008. "MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs," Nature, Nature, vol. 454(7205), pages 780-783, August.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7205:d:10.1038_nature07103
    DOI: 10.1038/nature07103
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature07103
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature07103?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Yue Deng & Yuqi Lin & Siyu Chen & Yuhang Xiang & Hongjia Chen & Shuyuan Qi & Hyung Suk Oh & Biswajit Das & Gloria Komazin-Meredith & Jean M. Pesola & David M. Knipe & Donald M. Coen & Dongli Pan, 2024. "Neuronal miR-9 promotes HSV-1 epigenetic silencing and latency by repressing Oct-1 and Onecut family genes," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:454:y:2008:i:7205:d:10.1038_nature07103. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.